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Nuffield Department of Women's & Reproductive Health sits within the Medical Sciences Division of the University of Oxford. The department encompasses multi-disciplinary research across four overarching themes; Cancer, Global Health, Maternal & Fetal Health and Reproductive Medicine & Genetics
Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children
1 in 400 people has a maternally‐inherited mutation in mitochondrial DNA (mtDNA) potentially causing incurable disease. In so‐called heteroplasmic disease, mutant and normal mtDNA co‐exist in the cells of carrier women. Disease severity depends on the proportion of inherited abnormal mtDNA molecules.