2010 Society for Reproduction and Fertility (SRF) New Investigator of the Year
Current Group Members:
- Briet Bjarkadottir (DPhil student)
- Tomi Adeniran (MSc student)
- Lindsay Baxter (DPhil student)
- Arwa Alageel (DPhil student)
- Charlotte Walker (DPhil student)
- Xi Wei (DPhil student)
- Eleni Papadopoulou (DPhil student)
Previous Group Members:
- Sairah Sheikh (DPhil student completed 2018)
- Belinda Lo (DPhil student completed 2018)
- Heidy Kaune (DPhil student completed 2015)
- Panayiota Ploutarchou (DPhil student completed 2015)
- Patrica Grasa Molina (Postdoctoral Fellow)
- Anna Deleva (Research Associate)
- Alice Christensen (Medical Student)
- 19 MSc student projects (2010-2018)
- 17 FHS/Undergraduate student projects (2008-2017)
- SRF vacation, ERASMUS, SSM and FY2 projects
- Prof. Norah Spears (University of Edinburgh)
- Profs. Evelyn Telfer and Richard Anderson, University of Edinburgh
- Dr. Rachel Cox (Uniformed Services University, Bethesda, USA)
- Prof. Jo Poulton, NDWRH
- Prof. Dagan Wells, NDWRH
Academic Groups and Editorial Boards
2013-present Editorial Board Member Journal Reproduction
2010-2013, 2019- Member of Council Society for Reproduction and Fertility
Opportunities to work with us
We are always keen to hear from people interested in working (Postdocs) or studying with us (e.g., DPhil, MSc by Research, ERASMUS students, summer students). Please contact Dr Williams by email in the first instance.
SRF Vacation Scholarships
SRF funded vacation scholarships are available to enable students to carry out research projects during the summer. Dr. Williams has hosted students before - get in contact to discuss these opportunities. 2019 open - deadline 18th April (http://srf-reproduction.org/grants-awards/grants/vacation-scholarships/).
Research in the Williams group has been funded by the Medical Research Fund, John Fell OUP, MRC, and the Society for Reproduction and Fertility.
BSc Hons, PhD
Principal Investigator/Research Group Leader; Lead of Ovarian Research for the Oxford Future Fertility Trust
- Lead for Oxford Future Fertility Trust; Cryopreservation Research Programme
- Chair of Examiners MSc Clinical Embryology
Dr. Williams (BSc Zoology, University of Aberdeen) completed her PhD at the Royal Veterinary College, London investigating nutritional regulation of ovarian function using sheep as a model for human. This involved collaborative studies in Glasgow, Dublin and Perth, Australia.
Following her PhD, Dr. Williams was awarded a Wain Fellowship and a Lalor Fellowship to work in Perth, Australia for 2 years. Dr. Williams then moved to the Albert Einstein College of Medicine in New York where she generated transgenic mouse models and demonstrated that oocyte glycans were not required in sperm-zona binding thus mooting hypotheses that had existed for almost 20 years. She also identified the oocyte as a key regulator of follicle selection and fertility since mice carrying oocytes lacking complex O-glycans had sustained increased fertility. She also identified the oocyte as having a key role in maintaining follicle integrity since follicles containing modified oocytes were able to join. Dr. Williams also revealed a crucial role for the oocyte in maintaining ovarian function since oocytes lacking both O- and N-glycans led to the onset of premature ovarian failure.
In 2008, Dr. Williams moved to the University of Oxford where she established her research group in the Dept of Physiology, Anatomy and Genetics investigating the role of the oocyte in regulating fertility and ovarian function supported by a MRC New Investigator grant. In 2011, Dr. Williams moved to the Nuffield Department of Women's and Reproductive Health (previously Obstetrics and Gynaecology).
Dr. Williams continues to work on premature ovarian insufficiency (supported by a MRC Centenary Award), and understanding ovarian function in health and disease. Dr. Williams has also expanded her programme of research to study human ovarian function and now leads the Oxford Ovarian Fertility Preservation Research Programme to develop and improve techniques for human fertility preservation.
More information is available about the studies being carried out by the Williams group on the Ovarian Research website.
In vitro and in vivo mouse follicle development in ovaries and reaggregated ovaries.
Lo BKM. et al, (2019), Reproduction, 157, 135 - 148
Oocyte-specific ablation of N- and O-glycans alters cumulus cell signalling and extracellular matrix composition
Lo BKM. et al, (2018), Reproduction, Fertility and Development
Validating the RedMIT/GFP-LC3 Mouse Model by Studying Mitophagy in Autosomal Dominant Optic Atrophy Due to the OPA1Q285STOP Mutation
Diot A. et al, (2018), Frontiers in Cell and Developmental Biology, 6
Oocyte stem cells: fact or fantasy?
Horan CJ. and Williams SA., (2017), Reproduction, 154, R23 - R35
Dysregulation of follicle development in a mouse model of premature ovarian insufficiency.
Grasa P. et al, (2016), Reproduction (Cambridge, England)
Podcast exploring the subject of origins is explored - from human fertilisation to the Big Bang. Includes parts 1, 2 and 3.