BSc (Hons) PhD
Postdoctoral Teaching Fellow
I completed a BSc with first class honours (2003) at the University of Adelaide followed by a Masters in Medial Science (2006) in Obstetrics and Gynaecology, supervised by Dr Robert Gilchrist and Prof David Armstrong, investigating the role of oocyte secreted factors using a mouse model. In 2007 I moved to the Nuffield Department of Obstetrics and Gynaecology to take charge of the flow cytometry facility in Prof Ian Sargent and Prof Chris Redman’s laboratory. During this time I obtained my Ph.D. (2011) in which I focused on characterising blood-derived microvesicles and exosomes in normal pregnancy and pre-eclampsia, using a range of techniques including flow cytometry and pioneered the use of Nanoparticle Tracking Analysis (NTA) for this purpose.
After completing my Ph.D. I continued to work in the same laboratory as a post-doctoral researcher/flow cytometer operator and I also took on the role as deputy laboratory manager. For the past three years, I have worked closely with Dr Dionne Tannetta to isolate, fractionate and characterise human placental syncytiotrophoblast microvesicles and exosomes in normal pregnancy and pre-eclampsia using a dual placental perfusion model. I am also working together with Dr Ingrid Granne to investigate the role of human follicular fluid microvesicles and exosomes in fertility.
- Characterisation of placental syncytiotrophoblast extracellular vesicles in normal pregnancy and pre-eclampsia
- Roles of follicular fluid extracellular vesicles in fertility
Trophoblast Glycoprotein (TPGB/5T4) in Human Placenta: Expression, Regulation, and Presence in Extracellular Microvesicles and Exosomes.
Alam SMK. et al, (2018), Reprod Sci, 25, 185 - 197
Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction.
Akbar N. et al, (2017), JCI insight, 2
ENDOTHELIUM-DERIVED EXTRACELLULAR VESICLES PROMOTE SPLENIC MONOCYTE MOBILISATION IN MYOCARDIAL INFARCTION
Akbar N. et al, (2017), HEART, 103, A150 - A150
Isolation of syncytiotrophoblast microvesicles and exosomes and their characterisation by multicolour flow cytometry and fluorescence Nanoparticle Tracking Analysis.
Dragovic RA. et al, (2015), Methods, 87, 64 - 74
UK–Russia Researcher Links Workshop: extracellular vesicles – mechanisms of biogenesis and roles in disease pathogenesis, M.V. Lomonosov Moscow State University, Moscow, Russia, 1–5 March 2015
Kapustin AN. et al, (2015), Journal of Extracellular Vesicles, 4, 28094 - 28094