I joined the Department of the Regius Professor of Medicine (Prof Sir Richard Doll) in 1970. I moved as a University Lecturer and Consultant in Obstetric Medicine to the Nuffield Department of Obstetrics and Gynaecology in 1976. I became a Clinical Professor in 1992. In addition to my research interests I created the High Risk Service in the Women’s Centre and many of its associated clinics.
I am a Fellow ad eundum of the Royal College of Obstetricians and Gynaecologists and recipient of the Chesley Award of the International Society for the Study of Hypertension in Pregnancy (2000), the Barnes Award, of the International Society of Obstetric Medicine (2002), ex-President of the International Society for the Study of Hypertension in Pregnancy (2006-2008) and Founder and Trustee of the charity Action on Pre-eclampsia.
MB, BChir, FRCP, FRCOG (ad eundum)
Emeritus Professor of Obstetric Medicine
- Co Investigator MRC Programme Grant
- Clinical Director, Oxford Centre for Fetal Monitoring Technologies
- Honorary Research Fellow, Lady Margaret Hall
- Co-Investigator, Global Pregnancy Collaboration, (Pittsburgh, USA)/
I have worked in Obstetric Medicine and investigated the pathogenesis, detection, prevention and treatment of pre-eclampsia since 1970.
I pioneered the concept of the role of a systemic inflammatory response both in normal pregnancy and the clinical stages of pre-eclampsia. I am currently engaged in a trial of selenium supplementation to help prevent pre-eclampsia.
My second and separate research interest is in computerised analysis of electronic fetal heart rate recordings (I am the Clinical Director of the Oxford Centre for Fetal Monitoring Technologies). Together with the late Prof Dawes a successful clinical system for antepartum records was developed and has been marketed since 1991. A current endeavour is to develop a comparable system for use in labour, based on a unique archive assembled in the Women’s Centre since 1992.
Sources of Funding
- The Wellcome Trust 2006- 2010
- The National Institute for Health Research 2007- 2012
- Unipath 2008- 2009
- Cyathus 2008- 2010
- Beckman Coulter
Update of syncytiotrophoblast derived extracellular vesicles in normal pregnancy and preeclampsia.
Tannetta D. et al, (2017), Journal of reproductive immunology, 119, 98 - 106
Effect of low-dose selenium on thyroid autoimmunity and thyroid function in UK pregnant women with mild-to-moderate iodine deficiency.
Mao J. et al, (2016), Eur J Nutr, 55, 55 - 61
Isolation of syncytiotrophoblast microvesicles and exosomes and their characterisation by multicolour flow cytometry and fluorescence Nanoparticle Tracking Analysis.
Dragovic RA. et al, (2015), Methods, 87, 64 - 74
Interleukin-1 family cytokines and their regulatory proteins in normal pregnancy and pre-eclampsia.
Southcombe JH. et al, (2015), Clin Exp Immunol, 181, 480 - 490
Diagnostic accuracy of placental growth factor and ultrasound parameters to predict the small-for-gestational-age infant in women presenting with reduced symphysis-fundus height.
Griffin M. et al, (2015), Ultrasound Obstet Gynecol, 46, 182 - 190