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Ana Kisovar

MD


MSc by Research Student & Student Committee Social Rep

  • PI Group: Dr Ingrid Granne

I am a medical doctor from Slovenia, graduated from the University of Ljubljana and the University of Heidelberg. Supervised by Dr Jennifer Southcombe, Assist. Prof. Ingrid Granne, and Assist. Prof. Christian Becker, I am focusing on the immunological background of infertility in patients with endometriosis,

Endometriosis is a disabling disease affecting approximately 190 million people with uterus worldwide with a significant proportion of them being subfertile. It is proposed that a change to the immune system is one of the possible causes. For the successful implantation of an embryo into the endometrium, immunological adaptations are made, and certain inflammatory pathways must be carefully regulated. CD8+ T cells are one such type of cell that could hinder establishment of pregnancy. Indeed, it has been clearly shown that in mice CD8+ T cells are effectively repelled from the site of embryo attachment. In my project, I am exploring if endometrial CD8+ T cells are altered in women with endometriosis, which could contribute to endometriosis-associated subfertility. 

As a research-oriented clinician, I am motivated by the burden of my friends and patients I see in clinic and would like to find a way to improve their quality of life as well as their opportunities for family planning.