William Cooke
BA BMBCh DPhil MRCOG PGDip (Health Research)
O&G Registrar, Honorary Research Fellow
- Specialty Trainee in Obstetrics and Gynaecology, Health Education England Thames Valley
- Postdoctoral researcher
- PI Group: Prof Manu Vatish
Biography
I studied preclinical medicine at Pembroke College, Oxford followed by clinical medicine at New College, Oxford. I undertook an NIHR Academic Foundation Programme in North Central Thames, with a research component at UCL investigating RNA signalling in ovarian carcinogenesis under the supervision of Prof Martin Widschwendter. I spent six months in Malawi in 2015, leading a clinical study investigating Acute Kidney Injury in pregnancy at Queen Elizabeth Central Hospital, Blantyre before moving back to Oxford to commence specialist training in Obstetrics and Gynaecology. During an NIHR Academic Clinical Fellowship in Oxford 2017-2020 I identified novel tRNA species within placental vesicles and was awarded a Wellcome Trust Doctoral Training Fellowship to investigate the role of tRNA signalling in preeclampsia. I completed my DPhil with commendation in 2023 and have ongoing research projects investigating the molecular pathways underlying placental dysfunction alongside completion of my clinical training.
International Awards
2021 Elsevier Trophoblast Research Award, International Federation of Placenta Associations
2020 First Prize, Blair Bell Research Competition, RCOG Annual Academic Meeting
2015 RCOG Eden Travelling Fellowship
Recent publications
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Small RNAs in the pathogenesis of preeclampsia.
Journal article
Cooke WR. et al, (2024), Placenta
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A method to isolate syncytiotrophoblast-derived medium-large extracellular vesicle small RNA from maternal plasma.
Journal article
Cooke WR. et al, (2024), Placenta
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Differential 5'-tRNA Fragment Expression in Circulating Preeclampsia Syncytiotrophoblast Vesicles Drives Macrophage Inflammation.
Journal article
Cooke WR. et al, (2024), Hypertension, 81, 876 - 886
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Protein Profiling of Placental Extracellular Vesicles in Gestational Diabetes Mellitus
Journal article
Kandzija N. et al, (2024), International Journal of Molecular Sciences, 25, 1947 - 1947
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ExoCounter Assays Identify Women Who May Develop Early-Onset Preeclampsia From 12.5 μL First-Trimester Serum by Characterizing Placental Small Extracellular Vesicles.
Journal article
Jiang S. et al, (2023), Hypertension