Luyao Wang
Postdoctoral Research Assistant in Translational Cancer Immunology
- PI group: Prof Ahmed Ahmed
Ovarian Cancer-Translational Cancer Immunology
Ovarian cancer is one of the main causes of death in women worldwide, despite new targeted therapies and immunotherapies, many patients with advanced-stage cancers still die, owing to metastatic disease. Adoptive T-cell therapy, involving the autologous or allogeneic transplant of tumour-infiltrating lymphocytes or genetically modified T cells expressing novel T-cell receptors or chimeric antigen receptors, has shown promise in the treatment of cancer patients. My ongoing work focuses on establishing a translation-ready therapeutic platform for treating ovarian cancer patients using adoptive T cell therapy.
I completed my Ph.D. with Professor Zhirong Zhang in the Pharmaceutics division of West China School of Pharmacy, Sichuan University. My Ph.D. project was about drug delivery systems and cancer therapy. During my Ph.D., I also have a one-year visiting study with prof. Walter Bodmer at the University of Oxford, doing research about colorectal cancer immunotherapy. From the drug delivery research for cancer to cancer immunotherapy and basic cancer biology exploration, this part of work really attracts me to continue. I am always passionate about cancer research, so I will continue the academic research in cancer biology and immunology with the goal to be an expert in this field and make some translations.
Key publications
-
Novel fibronectin-targeted nanodisk drug delivery system displayed superior efficacy against prostate cancer compared with nanospheres
Journal article
Wang L. et al, (2019), Nano Research, 12, 2451 - 2459
-
Polystyrene nanoparticles reduced ROS and inhibited ferroptosis by triggering lysosome stress and TFEB nucleus translocation in a size-dependent manner
Journal article
Li L. et al, (2019), Nano letters, 19, 7781 - 7792
-
Erythrocyte‐membrane‐camouflaged nanoplatform for intravenous glucose‐responsive insulin delivery
Journal article
Fu Y. et al, (2018), Advanced Functional Materials, 28
-
An injectable, low-toxicity phospholipid-based phase separation gel that induces strong and persistent immune responses in mice
Journal article
Han L. et al, (2016), Biomaterials, 105, 185 - 194
Recent publications
-
Co-delivery of TRAIL and paclitaxel by fibronectin-targeting liposomal nanodisk for effective lung melanoma metastasis treatment
Journal article
Huang S. et al, (2022), Nano Research, 15, 728 - 737
-
Integrin α2β1 Targeting DGEA-Modified Liposomal Doxorubicin Enhances Antitumor Efficacy against Breast Cancer
Journal article
Zhou B. et al, (2021), Molecular Pharmaceutics
-
OX40L blockade cellular nanovesicles for autoimmune diseases therapy
Journal article
Fu Y. et al, (2021), Journal of Controlled Release, 337, 557 - 570
-
Improved melanoma suppression with target-delivered TRAIL and Paclitaxel by a multifunctional nanocarrier
Journal article
Huang S. et al, (2020), Journal of Controlled Release, 325, 10 - 24