Contact information
Research groups
Colleges
Faheem Seedat
MBBCh, MMed, MRCP, FCP(SA), Cert Endocrinology and Metabolism (SA)
DPhil student, Endocrinologist
- PI Group: Prof Manu Vatish, NDWRH
- PI Group: Prof John Todd, Diabetes and Inflammation Laboratory, Centre for Human Genetics
Molecular Characterisation of the Placental-Islet Axis
BIOGRAPHY
I am a clinical endocrinologist having trained and worked in the South African healthcare sector. I completed my undergraduate medical degree at the University of Witwatersrand followed by specialist training in Internal Medicine and sub-specialist training in Endocrinology, Diabetes, and Metabolism.
I obtained a Masters in medicine from the University of Witwatersrand where I explored the effects of the widely used antiretroviral drug tenofovir on acute kidney injury in hospitalised HIV-positive patients, investigating its impact on disease severity and clinical outcomes.
Currently based at the John Radcliffe Hospital and the Centre for Human Genetics, my DPhil research centres on the intricate molecular signalling between the placenta and pancreatic islets. I aim to elucidate how placental hormones and extracellular vesicles (pEVs) influence maternal islet biology during normal pregnancy and gestational diabetes mellitus (GDM). This work aims to advance our understanding of the placental role in maternal metabolic adaptations and the pathophysiology of GDM.
AWARDS
2023 EYES Research Observership Programme, European Society of Endocrinology
Recent publications
-
Placental small extracellular vesicles from normal pregnancy and gestational diabetes increase insulin gene transcription and content in β cells
Journal article
Seedat F. et al, (2024), Clinical Science, 138, 1481 - 1502
-
Double malnutrition and associated factors in a middle-aged and older, rural South African population
Journal article
Seedat F. et al, (2024), BMC Nutrition, 10
-
Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry
Journal article
Ellis MJ. et al, (2024), Acta Neuropathologica, 147
-
Protein Profiling of Placental Extracellular Vesicles in Gestational Diabetes Mellitus
Journal article
Kandzija N. et al, (2024), International Journal of Molecular Sciences, 25, 1947 - 1947
-
Dyslipidaemia in patients with chronic kidney disease – a neglected cardiovascular risk factor
Journal article
Essop MR. et al, (2023), South African Medical Journal, 113, 35 - 40