I studied Biochemistry and Medicine at the University of Bristol, and following Specialist Registrar training in Chemical Pathology (Metabolic Medicine) at St Mary’s Hospital, London, undertook a DPhil at the University of Oxford (Somerville College) as an MRC Clinical Research Training Fellow, supervised by Prof Rajesh Thakker FRS. I then conducted postdoctoral research as an NIHR Academic Clinical Lecturer in Oxford before being appointed as a Senior Clinical Lecturer at the University of Liverpool. My work has focused on characterising the biochemical and molecular basis of mineral metabolism. I was awarded the 2013 ACB Professor’s Prize for Sustained Research in Clinical Biochemistry, and in 2017 was elected to the Association of Physicians of Great Britain and Ireland. In February 2019 I returned to the University of Oxford to establish a centre investigating the molecular endocrinology of lactation.
Family Larsson-Rosenquist Foundation
European Union Horizon 2020 Programme
Association of Physicians of Great Britain and Ireland
BSc (Hons), MSc, MBChB, DPhil (Oxon), MRCP, FRCPath
Director of the Larsson-Rosenquist Foundation Oxford Centre for the Endocrinology of Human Lactation
Prof Fadil Hannan was awarded the 2019 Clinical Endocrinology Trust Best Basic Science Abstract by the Society for Endocrinology (SfE). You can read an interview with him and learn more about challenges and breakthroughs in his work here.
Breastfeeding is of global importance for the promotion of optimal infant development and maternal health. However, the endocrine processes that ensure lactation adequacy remain to be elucidated. A world-class centre, funded by the Family Larsson-Rosenquist Foundation (FLRF), is being established at the University of Oxford to investigate the molecular endocrinology of human lactation.
Our objectives are to:
1) Characterise the endocrine control of lactation and establish reference standards applicable across a range of populations for the major hormones influencing human milk production and quality.
2) Define the signalling and crosstalk mechanisms between tissues that ensure lactation adequacy such as the pituitary, breast and bone.
3) Investigate how endocrine communication is mediated between mother and infant by measuring peptide and RNA signaling molecules in human milk.
4) Define the endocrine mechanisms by which lactation promotes infant growth and development, and reduces the maternal risk of type 2 diabetes and breast cancer.
Helen Price (Research Midwife)
Emma Newcombe (Project Manager)
Taha Elajnaf (Postdoctoral Researcher)
Xin Meng (Postdoctoral Researcher)
Hussam Rostom (DPhil student)
Professor Stephen Kennedy,
NDWRH, University of Oxford
Professor Rajesh Thakker FRS,
OCDEM, University of Oxford
Leach K. et al, (2020), Pharmacol Rev, 72, 558 - 604
Dershem R. et al, (2020), The American Journal of Human Genetics
Gorvin CM. et al, (2020), J Clin Endocrinol Metab
Activating mutations of the G-protein subunit a11 interdomain interface cause autosomal dominant hypocalcemia type 2
Gorvin C. et al, (2019), The Journal of Clinical Endocrinology & Metabolism
A Novel Ser182Cys Substitution in the Calcium Sensing Receptor Protein is Likely Pathogenic and Consistent with Molecular Diagnosis of Familial Hypocalciuric Hypercalcaemia Type 1
Healy U. et al, (2019), IRISH JOURNAL OF MEDICAL SCIENCE, 188, S231 - S231