Christina Aye
Contact information
Christina Aye
BMBCh (Oxon) MA Hons (Oxon) MRCOG DPhil (Oxon)
Honorary Senior Clinical Lecturer
- Consultant in Obstetrics and Fetal Medicine
- Fetal Monitoring Lead for OUH
- Academic Training Rep for HETV
Biography
I graduated from St John's College, Oxford University in 2006 and began my specialist training in Obstetrics and Gynaecology in Health Education Thames Valley in 2008. From 2014-2017, I undertook a DPhil in Cardiovascular Medicine under the supervision of Professor Paul Leeson (Cardiovascular Medicine) and Dr Ingrid Granne (NDWRH) investigating the effects of pregnancy complications on fetal and neonatal cardiovascular development. During this time I was awarded international and national prizes for my work including runner up in the RCOG Blair Bell Research Society Prize in 2017.
I was appointed as an NIHR Academic Lecturer in 2017 alongside a Subspecialty Training post in Maternal Fetal Medicine in Health Education Thames Valley following which I took up my current position as Consultant in Obstetrics and Fetal Medicine in Oxford University Hospitals NHS Foundation Trust in 2021. I was awarded an Honorary Clinical Lectureship from the University of Oxford in 2021 and continue to be research active.
I have a focussed research interest in long-term cardiovascular consequences of pregnancy complications, such as hypertensive disorders of pregnancy and preterm birth, in the mother and child and the pathological mechanisms behind them. I am currently a co-applicant on an MRC Programme Grant and a Principal Investigator for the ongoing CAREFOL-HT trial, a randomised controlled trial investigating the effects of 5-MHTF supplementation in early onset preeclampsia.
Key publications
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Association of Maternal Antiangiogenic Profile at Birth With Early Postnatal Loss of Microvascular Density in Offspring of Hypertensive Pregnancies
Journal article
Yu GZ. et al, (2016), Hypertension, 68, 749 - 759
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Disproportionate cardiac hypertrophy during early postnatal development in infants born preterm
Journal article
Aye CYL. et al, (2017), Pediatric Research, 82, 36 - 46
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Neonatal MicroRNA Profile Determines Endothelial Function in Offspring of Hypertensive Pregnancies
Journal article
Yu GZ. et al, (2018), Hypertension, 72, 937 - 945
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Neonatal autonomic function after pregnancy complications and early cardiovascular development
Journal article
Aye CYL. et al, (2018), Pediatric Research, 84, 85 - 91
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Do Young Women Need Treatment for Hypertension After Pregnancy Complications?
Journal article
Aye CYL. et al, (2018), Journal of the American Heart Association, 7
Recent publications
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Cardiac Remodeling After Hypertensive Pregnancy Following Physician-Optimized Blood Pressure Self-Management: The POP-HT Randomized Clinical Trial Imaging Substudy
Journal article
Kitt J. et al, (2024), Circulation, 149, 529 - 541
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Ultrasound predictors of adverse outcome in pregnancy complicated by pre-existing and gestational diabetes.
Journal article
Garbagnati M. et al, (2022), Acta Obstet Gynecol Scand, 101, 787 - 793
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Ebola virus disease in pregnancy: a systematic review and meta-analysis
Journal article
Kayem ND. et al, (2022), Transactions of The Royal Society of Tropical Medicine and Hygiene, 116, 509 - 522
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Lassa fever in pregnancy: a systematic review and meta-analysis
Journal article
Kayem ND. et al, (2020), Transactions of The Royal Society of Tropical Medicine and Hygiene, 114, 385 - 396
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Fertility issues and pregnancy outcome in Turner Syndrome
Journal article
Calanchini M. et al, (2020), Fertility and Sterility