Elucidating the biology of the menstrual cycle using histology and gene expression (Dr Hannah Currant & Prof. Christoffer Nellaker)
PROJECT TITLE
Elucidating the biology of the menstrual cycle using histology and gene expression.
SUPERVISORS
DESCRIPTION OF PROJECT
The menstrual cycle and its accompanying hormonal fluctuations are thought to impact broader health. Furthering our understanding of the biology underlying the menstrual cycle - including the genetic control of it and the physiological changes it causes in reproductive tissues - could help us understand its downstream effects that may require therapeutic intervention.
A project within the group would focus on utilising histology computer vision approaches and combining it with multiomics data to capture and characterise stages of the menstrual cycle.
For instance, we are interested in whether using histology imaging of ovaries can stage an individual within their menstrual cycle. Utilising histology images as a data source will also enable the possibility of extracting morphological phenotypes at different stages of the menstrual cycle for further investigation. This may also enable us to move away from considering menstrual phases as a fixed and categorical variable to a continuous and personal variable that may be integrated into other aspects of healthcare.
We will then integrate this with multiomics data including genetics and gene expression data to better understand the biological processes underlying the changes seen across the menstrual cycle. Looking for gene expression signatures of menstrual phases could allow us to understand how the menstrual cycle interacts with other systemic biological processes. It may also allow us to ask new questions about the health implications of the menstrual cycle. This may include looking at the interaction with medications, which is a main focus of the group.
TRAINING OPPORTUNITIES
- Research training in machine learning, statistics, quantitative genetics and beyond
- Membership to journal clubs and research group meetings to understand current research landscape, cutting edge methodology and interdisciplinary applications
- Skills training in presentation, scientific writing, funding applications and scientific leadership
- Training plans will be developed holistically to benefit the scientific needs and interests, as well as the career goals of the individual.
Funding Information
The position is not currently funded and therefore the candidate will need to secure funding.
HOW TO APPLY
To apply for this research degree, please click here.