Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.
Skip to main content

Circulating sFlt-1 increases significantly in pregnancy compared to the non-pregnant state and even more so in the event of preeclampsia. We set out to determine if circulating sFlt-1 is placentally derived in normal pregnancy. Paired uterine and peripheral vein samples were collected at time of caesarean section. A follow up peripheral sample was collected in the postpartum period. There was a significant sFlt-1 gradient between uterine and peripheral veins. sFlt-1 levels dropped significantly when the placenta has been removed, i.e. postnatally. This is in keeping with the placenta being the main site of sFlt-1 production in normal pregnancies.

Original publication

DOI

10.1016/j.preghy.2019.03.013

Type

Journal article

Journal

Pregnancy Hypertens

Publication Date

04/2019

Volume

16

Pages

145 - 147

Keywords

Placenta, Preeclampsia, Pregnancy, Uterine vein, sFlt-1