Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Pulsed field gel electrophoresis was carried out on lymphocyte DNA obtained from ten patients with the inherited premalignant condition adenomatous polyposis coli and a similar number of control samples to search for large scale molecular rearrangements in the vicinity of the APC locus. DNA from one patient showed a rearranged pattern which was interpreted as evidence for an inversion of approximately 150 kb, changing the transcriptional orientation of the neighbouring MCC gene and bringing it closer to APC. Such an interpretation was supported by fluorescent in situ hybridization data.


Journal article


Ann Hum Genet

Publication Date





169 - 178


Adenomatous Polyposis Coli, Chromosome Inversion, Chromosomes, Artificial, Yeast, DNA, Electrophoresis, Agar Gel, Gene Rearrangement, Genes, APC, Genes, MCC, Humans, In Situ Hybridization, Fluorescence, Lymphocytes, Precancerous Conditions, Restriction Mapping