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OBJECTIVE: To assess the morbidity associate with rectosigmoid resection (RSR) in patients with stage IIIC-IV ovarian cancer (OC) undergone primary debulking surgery (PDS) vs. interval debulking surgery (IDS) after neoadjuvant chemotherapy (NACT). METHODS: From the Oxford Advanced OC database, we retrieved all patients who underwent surgery between January 2009 and July 2016 and included all patients who underwent RSR. We compared the rates of overall related and not-related morbidity and bowel diversion in patients undergone RSR during PDS vs. IDS. RESULTS: Three hundred and seventy-one patients underwent surgery: 126 in PDS group and 245 in IDS group. Fifty-two patients in the PDS group (41.3%) and 65 patients in IDS group (26.5%) underwent RSR (p<0.001). Overall not related morbidity rate was 37.5% and 28.6%, p=0.625. Bowel specific complications affected 16.3% vs. 11.1% of the patients (p=0.577). IDS group had higher rate of bowel diversion compared with PDS (46.0% vs. 26.5%, p=0.048). CONCLUSION: NACT was associated to an overall reduced rate of RSR compared to IDS. No differences in overall related and not-related complications in patients requiring RSR were seen between the 2 groups. Patients in the IDS group had a significantly higher rate of bowel diversion.

Original publication

DOI

10.3802/jgo.2019.30.e25

Type

Journal article

Journal

J Gynecol Oncol

Publication Date

03/2019

Volume

30

Keywords

Anastomotic Leak, Cytoreduction Surgical Procedures, Ovarian Neoplasms, Surgical Stomas, Anastomosis, Surgical, Chemotherapy, Adjuvant, Colon, Sigmoid, Cytoreduction Surgical Procedures, Female, Humans, Middle Aged, Neoadjuvant Therapy, Ovarian Neoplasms, Postoperative Complications, Rectum, Retrospective Studies, Surgical Stomas