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The prognosis of brain cancer glioblastoma (GBM) is poor, and despite intense research, there have been no significant improvements within the last decade. This stasis implicates the need for more novel therapeutic investigation. One such option is the use of nanoparticles (NPs), which can be beneficial due to their ability to penetrate the brain, overcome the blood-brain barrier and take advantage of the enhanced permeation and retention effect of GBM to improve specificity. Rare earth elements possess a number of interesting natural properties due to their unique electronic configuration, which may prove therapeutically advantageous in an NP formulation. The underexplored exciting potential for rare earth elements to augment the therapeutic potential of NPs in GBM treatment is discussed in this review.

Original publication

DOI

10.2217/nnm-2017-0193

Type

Journal article

Journal

Nanomedicine (London, England)

Publication Date

10/2017

Volume

12

Pages

2389 - 2401

Addresses

Medical Sciences Division, University of Oxford, Oxford, UK.