Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children
Bima A., Pezic A., Sun C., Cameron FJ., Rodda C., van der Mei I., Chiaroni-Clarke R., Dwyer T., Kemp A., Qu J., Carlin J., Ellis JA., Ponsonby A-L.
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background:</jats:title><jats:p>Vitamin D deficiency has been associated with adverse health outcomes. We examined genetic and environmental determinants of serum 25(OH)D</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>The study sample consisted of 322 healthy Australian children (predominantly Caucasians) who provided a venous blood sample. A parental interview was conducted and skin phototype and anthropometry measures were assessed. Concentrations of 25(OH)D</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>Deseasonalised log 25(OH)D</jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p>Environmental factors and genetic factors contributed to both vitamin D metabolite concentrations. The intriguing finding that the higher ambient UVR contributed to higher 1,25(OH)</jats:p></jats:sec>