BaselineIn VitroActivities of the Antimalarials Pyronaridine and Methylene Blue against Plasmodium falciparum Isolates from Kenya
Okombo J., Kiara SM., Mwai L., Pole L., Ohuma E., Ochola LI., Nzila A.
ABSTRACTWe have analyzed thein vitroactivities of pyronaridine and methylene blue against 59Plasmodium falciparumisolates from Kenya in association with polymorphisms inPfcrt(codon 76),Pfmdr1(codon 86), andPfnhe(full sequence). The median inhibitory concentrations that kill 50% of parasites were 13.5 and 3.3 nM for pyronaridine and methylene blue, respectively. Their activities were not associated with polymorphisms in these genes. The drugs' highin vitroactivities indicate that they would be efficacious against Kenyan isolatesin vivo.