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ABSTRACTWe have analyzed thein vitroactivities of pyronaridine and methylene blue against 59Plasmodium falciparumisolates from Kenya in association with polymorphisms inPfcrt(codon 76),Pfmdr1(codon 86), andPfnhe(full sequence). The median inhibitory concentrations that kill 50% of parasites were 13.5 and 3.3 nM for pyronaridine and methylene blue, respectively. Their activities were not associated with polymorphisms in these genes. The drugs' highin vitroactivities indicate that they would be efficacious against Kenyan isolatesin vivo.

Original publication

DOI

10.1128/aac.05454-11

Type

Journal article

Journal

Antimicrobial Agents and Chemotherapy

Publisher

American Society for Microbiology

Publication Date

02/2012

Volume

56

Pages

1105 - 1107