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<jats:title>ABSTRACT</jats:title><jats:p>We have analyzed the<jats:italic>in vitro</jats:italic>activities of pyronaridine and methylene blue against 59<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">Plasmodium falciparum</jats:named-content>isolates from Kenya in association with polymorphisms in<jats:italic>Pfcrt</jats:italic>(codon 76),<jats:italic>Pfmdr1</jats:italic>(codon 86), and<jats:italic>Pfnhe</jats:italic>(full sequence). The median inhibitory concentrations that kill 50% of parasites were 13.5 and 3.3 nM for pyronaridine and methylene blue, respectively. Their activities were not associated with polymorphisms in these genes. The drugs' high<jats:italic>in vitro</jats:italic>activities indicate that they would be efficacious against Kenyan isolates<jats:italic>in vivo</jats:italic>.</jats:p>

Original publication

DOI

10.1128/aac.05454-11

Type

Journal article

Journal

Antimicrobial Agents and Chemotherapy

Publisher

American Society for Microbiology

Publication Date

02/2012

Volume

56

Pages

1105 - 1107