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In a prospective cohort of 181 individuals followed up since childhood--when aged 9, 12 and 15 years--patients with a family history of premature coronary heart disease (n=18) had higher left ventricular mass index in adulthood--at mean age of 31 years--compared with those without (mean±standard error 39.1±1.9 versus 34.6±0.7 g/m(2.7), p=0.04). The correlation between adult left ventricular mass index and child triglycerides (r=0.66, p=0.04 versus r=-0.03, p=0.75; p(diff)=0.02) and diastolic blood pressure (r=0.65, p=0.02 versus r=0.16, p=0.07; p(diff)=0.05) was stronger among those with a family history of coronary heart disease than in those without. Although preliminary, these data suggest that the higher left ventricular mass index among adults with a family history might be explained by their increased susceptibility to child cardio-metabolic risk factors.

Original publication

DOI

10.1017/S1047951113001571

Type

Journal article

Journal

Cardiol Young

Publication Date

10/2014

Volume

24

Pages

938 - 940

Keywords

Adolescent, Australia, Child, Coronary Disease, Female, Follow-Up Studies, Genetic Predisposition to Disease, Heart Ventricles, Humans, Hypertrophy, Left Ventricular, Incidence, Male, Prospective Studies, Risk Factors, Young Adult