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Three types of disorders of human pregnancy with a possible immune etiology have been discussed. Pre-eclampsia and recurrent abortion may result from a failure of a maternal immunoregulatory response to trophoblast but the evidence is incomplete and circumstantial. There are several fetal problems which may arise because of transfer of maternal allo-, iso-, or autoantibodies to the fetus. Third, maternal graft-versus-fetal-host disease occurs rarely and may present in a delayed and incomplete way as severe combined immunodeficiency.


Journal article


Oxf Rev Reprod Biol

Publication Date





223 - 265


Abortion, Habitual, Female, Graft vs Host Disease, HLA Antigens, Humans, Immune System Diseases, Maternal-Fetal Exchange, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Trophoblasts