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The mixed lymphocyte reactions (MLR) of normal pregnant women and their non-pregnant HLA identical sisters have been compared, using paternal and unrelated lymphocytes as stimulator cells. Primary and secondary responses were differentiated by studying 7 day MLR time courses. All responses were of a primary nature, with neither stimulation nor suppression of the maternal MLR. These data clearly demonstrate the absence of maternal cellular sensitization to fetal (paternal) HLA.


Journal article


Clin Exp Immunol

Publication Date





91 - 94


Fathers, Female, HLA Antigens, Humans, Immunity, Cellular, Lymphocyte Activation, Lymphocyte Culture Test, Mixed, Male, Mothers, Pregnancy