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The renin-angiotensin system not only plays a critical role in blood pressure control but is also involved in learning and memory mechanisms. In addition to angiotensin (Ang) II, Ang-(1-7) may also have important biological activities in the brain. Here, we show for the first time that Ang-(1-7) enhances long-term potentiation (LTP) in the CA1 region of the hippocampus. Our studies with AT1 receptor antagonists and selective Ang-(1-7) receptor antagonists demonstrate the existence of a distinct Ang-(1-7) receptor in the brain, the G-protein-coupled receptor Mas, encoded by the Mas protooncogene. We also show that the genetic deletion of this receptor abolishes the Ang-(1-7)-induced enhancement of LTP. Thus, we firstly demonstrate that Ang-(1-7) influences the induction of LTP in limbic structures implicating its distinct function in learning and memory mechanisms; secondly, we have identified Mas as a functional receptor for Ang-(1-7) in the brain.

Original publication




Journal article


Mol Cell Neurosci

Publication Date





427 - 435


Angiotensin I, Angiotensin II Type 1 Receptor Blockers, Animals, Dose-Response Relationship, Drug, Electric Stimulation, Enzyme Inhibitors, Hippocampus, Learning, Long-Term Potentiation, Male, Memory, Mice, Mice, Knockout, Neurons, Organ Culture Techniques, Peptide Fragments, Proto-Oncogene Proteins, Receptor, Angiotensin, Type 1, Receptors, G-Protein-Coupled, Up-Regulation