The Association Between Periconceptual Maternal Dietary Patterns and Miscarriage Risk in Women With Recurrent Miscarriages: A Multicentre Cohort Study.
Chung Y., Melo P., Easter C., Price MJ., Dhillon-Smith R., Quenby S., Devall A., Coomarasamy A.
OBJECTIVE: To examine the association between periconceptual maternal diet and miscarriage risk among women with recurrent miscarriages. DESIGN: Prospective multicentre cohort study (Tommy's Net). SETTING: Three university hospital research centres in the United Kingdom. POPULATION: 1035 women with a baseline history of two or more miscarriages. METHODS: We analysed baseline dietary data from a 10-item Food Frequency Questionnaire (FFQ). For individual food category analyses, we used multivariable Poisson regression following adjustment for maternal confounders and paternal dietary patterns. For whole diet analyses, ordinal principal component analysis (PCA) was used to identify common dietary patterns. Results were presented as relative risks (RR) with 95% confidence intervals (CI) and accompanying p-values. MAIN OUTCOME MEASURES: Miscarriage rate, defined as the rate of spontaneous pregnancy loss (