Quantitative Antibody Levels in Hospital Workers after Receiving three Doses of CoviD-19 vaccines
Sitompul PA., Mariana N., Budiman E., Tanjung DW., Ariesanty B., Hartono TS., Jahiroh J., Ernita C., Dinar A., Puspitasari A., Herlina H., Suliati S., Murtiani F., Maemun S., Syahril M.
Hospital workers were at high risk for SARS-CoV-2 infection and the first population with authorized access to the three doses of vaccination against SARS-CoV-2 antigen. The study was aimed to compare SARS-CoV-2 antibody levels among hospital workers receiving the three doses of Covid-19 vaccines with a history of Covid-19 infection versus those without a history of infection. A cross sectional study was conducted at the Sulianti Saroso Infectious Disease Hospital (SSIDH) in December 2021. The inclusion criteria were hospital workers in both subjects with and without previous Covid-19 infection and those who had received 3 doses of Covid-19 vaccines. Anti SARS-CoV-2 antibody levels measured by the Architect of SARS-CoV-2 IgG II Quant. There were 75 participants in the study, the median of anti SARS CoV-2 levels reported 8724.4 AU/mL (3396.8, 15773.2 AU/mL, Interquartile range). They were divided into 2 groups according to the status of prior Covid-19 infection, hospital workers with and without previous of Covid-19 infection. There was no significance difference in antibody less than 25.000 AU/mL between hospital worker with and without previous Covid-19 infection (p=1,000). Meanwhile, the median of antibody levels was seen in the interval between the 3rd dose of vaccine within 1 month; 2 to 3 months; 4 to 5 months before the antibody measurement (14576.5 AU/mL;12407.4 AU/mL; 5778.1 AU/mL, respectively). In this study, after three doses of Covid-19 vaccines, there was no significance difference in antibody levels of hospital worker with and without previous Covid-19 infection.