Second and third trimester estimation of gestational age using ultrasound or maternal symphysis‐fundal height measurements: A systematic review

AbstractBackgroundAccurate assessment of gestational age (GA) is important for managing pregnancies at an individual level and monitoring preterm birth rates at a population level.ObjectivesAs many women first seek antenatal care in late pregnancy, our aim was to assess the methodology of studies reporting equations for estimating GA after 20 weeks’ gestation using ultrasound or symphysis‐fundal height (SFH) measurements.Search strategySix electronic databases were searched for studies published from January 1970 to April 2021.Selection criteriaStudies were included if they contained a formula using SFH or ultrasound‐measured biometry to estimate GA after 20 weeks in healthy singleton pregnancies.Data collection and analysisTwo reviewers and a statistician reviewed study design, statistical methods, and reporting methods using 29 criteria. Each article was awarded an overall quality score, predefined as the percentage of the 29 criteria scored at low risk of bias. 95% prediction intervals were calculated for studies that used recommended first trimester dating to confirm true GA.Main resultsThe search yielded 4209 results. Ninety‐seven full‐text articles were included in the analysis. The mean quality score was 32% (range 7%–97%). Only 10 articles scored low risk in 18 or more criteria. Their formulas estimated GA using one or more ultrasound‐measured biometry parameters and SFH measurements. Twenty‐three articles used recommended first trimester dating. A single‐parameter formula using transcerebellar diameter (TCD) gave the lowest 95% prediction interval.ConclusionsThere is considerable methodological heterogeneity in studies developing equations for estimating GA. Formulas using ultrasound‐based measurements more accurately estimated GA after 20 weeks than formulas using SFH measurement. While the clinical priority remains promotion of early engagement with antenatal care, we suggest unified standards for GA and growth assessment.Tweetable abstractMany vulnerable women seek antenatal care late in pregnancy. How should gestational age be determined? We examine all available studies estimating GA >20 weeks. Ultrasound is much better than fundal height, and using cerebellar measurement appears to be the most accurate.