Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.
Hawe JS., Wilson R., Schmid KT., Zhou L., Lakshmanan LN., Lehne BC., Kühnel B., Scott WR., Wielscher M., Yew YW., Baumbach C., Lee DP., Marouli E., Bernard M., Pfeiffer L., Matías-García PR., Autio MI., Bourgeois S., Herder C., Karhunen V., Meitinger T., Prokisch H., Rathmann W., Roden M., Sebert S., Shin J., Strauch K., Zhang W., Tan WLW., Hauck SM., Merl-Pham J., Grallert H., Barbosa EGV., MuTHER Consortium None., Illig T., Peters A., Paus T., Pausova Z., Deloukas P., Foo RSY., Jarvelin M-R., Kooner JS., Loh M., Heinig M., Gieger C., Waldenberger M., Chambers JC.
We determined the relationships between DNA sequence variation and DNA methylation using blood samples from 3,799 Europeans and 3,195 South Asians. We identify 11,165,559 SNP-CpG associations (methylation quantitative trait loci (meQTL), P