Pregnancies in women with Turner syndrome: a retrospective multicentre UK study.
Cauldwell M., Steer PJ., Adamson D., Alexander C., Allen L., Bhagra C., Bolger A., Bonner S., Calanchini M., Carroll A., Casey R., Curtis S., Head C., English K., Hudsmith L., James R., Joy E., Keating N., MacKiliop L., McAuliffe F., Morris RK., Mohan A., Von Klemperer K., Kaler M., Rees DA., Shetty A., Siddiqui F., Simpson L., Stocker L., Timmons P., Vause S., Turner HE.
OBJECTIVE: To determine the characteristics and outcomes of pregnancy in women with Turner syndrome. DESIGN: Retrospective 20-year cohort study (2000-20). SETTING: Sixteen tertiary referral maternity units in the UK. POPULATION OR SAMPLE: A total of 81 women with Turner syndrome who became pregnant. METHODS: Retrospective chart analysis. MAIN OUTCOME MEASURES: Mode of conception, pregnancy outcomes. RESULTS: We obtained data on 127 pregnancies in 81 women with a Turner phenotype. All non-spontaneous pregnancies (54/127; 42.5%) were by egg donation. Only 9/31 (29%) pregnancies in women with karyotype 45,X were spontaneous, compared with 53/66 (80.3%) pregnancies in women with mosaic karyotype 45,X/46,XX (P