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Despite more cancers in young men over the past two decades, improvements in therapies give a greater chance to live full lives following treatment. Sperm genomic quality is variable following cancer diagnosis, so its assessment is important if sperm cryopreservation is being considered. Here, we evaluated DNA damage using two DNA damage assays: an alkaline and for the first time, a neutral Comet assays in men presenting with testicular cancer (n = 19 for alkaline and 13 for neutral group) and lymphoma (n = 13 for alkaline and 09 for neutral group) compared with fertile donors (n = 20 for alkaline and 14 for neutral group). No significant differences were observed in any semen analysis parameters. In contrast, sperm DNA damage was higher in men with testicular cancer than in donors as assessed by both the alkaline (12.4% vs. 37.4%, p 

Original publication

DOI

10.1111/andr.12429

Type

Journal article

Journal

Andrology

Publication Date

01/2018

Volume

6

Pages

230 - 235

Keywords

Comet assay, cancer, male infertility, sperm DNA damage, Comet Assay, DNA Fragmentation, Humans, Lymphoma, Male, Semen Analysis, Spermatozoa, Testicular Neoplasms