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ObjectivesTo understand if pregnancy unmasks previously silent cardiovascular (CV) adverse factors, or initiates lasting injury.MethodsPre-pregnancy and during pregnancy CV risk factors (blood pressure, fasting lipids, and glucose) from 296 women belonging to studies in the International Childhood Cardiovascular Cohort (i3C) Consortium, a group of studies assessing the relationship between child and adolescent CV risk factors and adult outcomes, were used. Correlation coefficients between the pre- and during pregnancy measures were calculated, and the mean difference between the measures was modeled with adjustment for age, body mass index, race, smoking, and study.ResultsMeasures were strongly correlated at pre- and during-pregnancy visits (p ConclusionsPre- and during-pregnancy CV risk factors are moderately well correlated. This may indicate that susceptible women enter pregnancy with higher risk rather than pregnancy inducing new vascular or metabolic effects.

Original publication




Journal article


The journal of obstetrics and gynaecology research

Publication Date



Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.


i3C Consortium