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Gastrointestinal stromal tumours (GISTs) are rare - and rectovaginal extragastrointestinal stromal tumours (RV-EGISTs) even rarer. We share a case of RV-EGIST, complemented by high-quality radiological and surgical images. A review of current literature pertaining to RV-EGIST is also included. Our case report highlights the diagnostic challenge presented by extragastrointestinal stromal tumours. Differentiated from overlapping pathologies only by targeted application of immunohistopathology and cytogenetics, the inclusion of RV-EGIST in the differential diagnosis of a rectovaginal tumour is essential to making this correct diagnosis. Primary surgery is the treatment of choice for RV-EGIST if complete cytoreduction can be achieved, combined with adjuvant tyrosine kinase inhibitor (TKI) therapy for those with high-risk features to further reduce rates of future recurrence.

Original publication

DOI

10.1136/bcr-2020-237669

Type

Journal article

Journal

BMJ Case Rep

Publication Date

08/03/2021

Volume

14

Keywords

gynaecological cancer, pathology, surgical oncology, Diagnosis, Differential, Fascia, Gastrointestinal Stromal Tumors, Humans, Neoplasm Recurrence, Local, Soft Tissue Neoplasms