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OBJECTIVE: To determine the rate of occult malignancy in patients undergoing prophylactic bilateral salpingo-oophorectomy in Northern Sydney. METHODS: A retrospective case series of 45 consecutive patients who underwent prophylactic bilateral salpingo-oophorectomy between 2004 and March 2008. RESULTS: Five (11%) cases of occult neoplasia were found in 45 patients. This included 3 cases of micro-invasive serous carcinoma of the fallopian tube, 1 case of in situ carcinoma in the fallopian tube and 1 case of metastatic breast cancer in the ovary. All cases of primary neoplasia were in the fimbrial end of the fallopian tube. CONCLUSIONS: The importance of complete removal of the fallopian tubes and ovaries and the rigorous systematic pathological examination of these specimens are demonstrated in this case series. It supports emerging evidence that the fimbrial end of the fallopian tube is an important site of genesis of cancer in BRCA1/2 mutation carriers.

Original publication

DOI

10.1111/IGC.0b013e3181a1b5dc

Type

Journal article

Journal

Int J Gynecol Cancer

Publication Date

07/2009

Volume

19

Pages

826 - 829

Keywords

Aged, Breast Neoplasms, Carcinoma in Situ, Cystadenocarcinoma, Serous, Fallopian Tube Neoplasms, Female, Genes, BRCA1, Genes, BRCA2, Genetic Predisposition to Disease, Germ-Line Mutation, Humans, Middle Aged, Ovarian Neoplasms, Ovariectomy, Retrospective Studies, Risk Factors, Treatment Outcome