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Chorev et al (Reports, 16 November 2018, p. 829) describe mass spectrometry on mitochondrial membrane proteins ionized directly from their native environment. However, the assignments made to measured masses are incorrect or inconclusive and lack experimental validation. The proteins are not in their "native" condition: They have been stripped of tightly bound lipids, and the complexes are fragmented or in physiologically irrelevant oligomeric states.

Original publication

DOI

10.1126/science.aaw9830

Type

Journal article

Journal

Science (New York, N.Y.)

Publication Date

07/11/2019

Volume

366

Addresses

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. jh@mrc-mbu.cam.ac.uk ek@mrc-mbu.cam.ac.uk walker@mrc-mbu.cam.ac.uk.