Supplementary Figure S1 from Oxford Classic–Defined EMT Risk Stratification of High-Grade Serous Ovarian Cancer for Guiding Treatment Decisions
Rai L., Ravaggi A., Bignotti E., Hollis RL., Garsed DW., Pandey A., Papalois KB., Patel F., Kamel Y., Campo L., Easton A., Nulsen J., Roskams-Hieter B., Artibani M., Wang L., Hussain N., Wang L., Zaarour N., Aggarwal A., Ahmed-Ebbiary A., Al-Deka A., Churchman M., Herrington CS., Ardighieri L., Ferrari F., Yau C., Gourley C., Odicino F., Ahmed AA.
Supplementary Fig. S1. [A] Violin plot illustrating the distribution of OxC-EMT scores in 12 independent datasets. [B] Line graph of Hazard Ratios and associated p-values derived from fitting a loop structured cox regression model to the combined set. Y-axis on the left-hand side represents the scale for Hazard Ratio and the y-axis on the right-hand side represents the scale for the p-value. [C] Plot displaying median survival time (in days) for OxC-EMT-high (solid red line) and corresponding 95% CI (dashed red line) and median survival for OxC-EMT-low (solid blue line) and corresponding 95% CI (dashed blue line). [D] Kaplan-Meier survival plot demonstrating the probability of overall survival for OxC-EMT-high/BRCAmutated, OxC-EMT-high/BRCAwildtype, OxC-EMT-low/BRCAmutated and OxC-EMT-low/BRCAwildtype patients in the Scottish cohort. [E] Kaplan-Meier survival plot demonstrating the probability of overall survival for OxC-EMT-low risk patients in the Combined set with Oxford Classic subtypes, Cell Cycle, Differentiated, KRT17 and Mixed.