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NEAT1 is a highly abundant long non-coding RNA that is an essential scaffold for the assembly of a class of nuclear ribonucleoprotein bodies called paraspeckles. Paraspeckles formation is elevated by a wide variety of cellular stressors and modulate cellular processes by sequestering proteins or RNA molecules. Importantly, abnormal NEAT1 expression is associated with serious diseases such as neurodegenerative disorders and cancer. In this talk I will present data suggesting a crosstalk between paraspeckles and lysosomes, which might be relevant in human pathologies.