Unhappy mitochondria stress out lysosomes and keep away from ER

Dr Nuno Raimundo is a Principal Investigator in the Multidisciplinary Institute of Ageing, Faculty of Medicine, University of Coimbra, Portugal.  

 'Unhappy mitochondria stress out lysosomes and keep away from ER'

Cells work as a small machine in which the different components (organelles) are coordinated with each other, as in a car. When that coordination between organelles is lost, there is development of pathologies that affect muscles (including the heart), liver, eyes, ears, and nervous system. Our goal is to understand how cellular organelles crosstalk with each other so that we can avoid diseases caused by the loss of that coordination. We use mammalian models (mouse) and cellular (human, mouse, rat) to tackle these questions and define novel therapeutic strategies to neurodegenerative, muscular and other diseases