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Nancy Zaarour

Title: Unleash the potential of T-cell mediated immune response within the Fallopian tube for ovarian cancer prevention.

Abstract: High-grade serous ovarian cancer (HGSC) is the most lethal histotype of ovarian cancer and most cases present with metastasis and late-stage disease. Over the last few decades, the overall survival for patients has not significantly improved, and there are limited targeted treatment options. The fallopian tube is now believed to be the origin of most high grade serous ovarian cancers. Exploring the anti-tumor potential of immune cells in the fallopian tube is essential to implement preventative strategies. In spite of documented evidence of immune cell infiltration of the connective tissue surrounding serous tubal intraepithelial carcinomas (STICs), the ovarian cancer precursor, the direct demonstration of the ability of tissue resident memory T cells (TRMs) in eliciting an anti-tumour immune response has not been previously shown. In this talk, we will discuss our recent findings showing how TRMs that reside in non-cancerous fallopian tubes recall a memory response by reacting to tumour organoids derived from omental metastases in the same patient. Moreover, these memory cells induce apoptosis in tumour-derived organoids indicating that they possess cytotoxic ability. We will also shed light on the discovery of a novel T cell subset with an immune-epithelial phenotype. Harnessing the power of TRMs could guide the design of novel vaccination strategies to prevent ovarian cancer.

 

Karl Morten

Title: TBC

Abstract: TBC