Krina Zondervan

Contact information

Email
krina.zondervan@wrh.ox.ac.uk

Telephone
+44 (0)1865 740382 / 221003 (PA)

Colleges

St Edmund Hall

GROUP MEMBERS

Rebecca Chaplin (PA to Krina Zondervan)

Kelly Barrett (Research Nurse)

Lisa Buck (Research Nurse)

Josie Everatt (DPhil Student)

Kurtis Garbutt (Data Scientist and Programme Manager)

Tatjana Gibbons (DPhil Student)

Omero Poli Netto (Visiting Senior Research Fellow)

Nilufer Rahmioglu (Senior Research Fellow)

Bhuchitra Singh (DPhil Student)

Fitnat Topbas (DPhil Student)

Outi Uimari (Visiting Clinical Research Fellow)

Yifan Wang (DPhil Student)

Affiliated:

Lydia Coxon (Postdoc, Vincent group)

Lysia Demetriou (Postdoc, Vincent group)

Rebecca Dragovic (Senior Postdoctoral Fellow)

Rachel Reid-McCann (Postdoc, Vincent group)

Katy Vincent (Professor of Gynaecological Pain)

Biography

I came to Oxford on an Erasmus exchange scholarship in 1993, after an MSc in Biomedical Sciences (Cum Laude, 1995), at Leiden University, the Netherlands. Following a DPhil (NDOG/DPH, St Edmund Hall, 1999) on the epidemiology of chronic pelvic pain, I was awarded an MRC Training Research Fellowship in Genetic Epidemiology based at the Wellcome Trust Centre for Human Genetics, which included an MSc in Genetic Epidemiology (Erasmus University Rotterdam, Netherlands, 2001) and research periods at the Queensland Institute for Medical Research, Australia and the Dept of Human Genetics, University of Pittsburgh, USA.

In 2007, I was awarded a Wellcome Trust Research Career Development Fellowship and in 2012 became Co-Director of the Endometriosis CaRe centre in Oxford (with Christian Becker). I was appointed as Professor of Reproductive and Genomic Epidemiology in 2015. I am Fellow by Special Election at St Edmund Hall. Awards include Outstanding Female Scientist (AcademiaNet, Wellcome Trust nomination, 2013), Honorary Skou Professorship at the University of Aarhus, Denmark (2019), Honorary Fellowship ad eundem by the Royal College of Obstetricians and Gynaecologists, UK (2022), and Honorary Fellowship of the Academy of Medical Sciences (2024). I have served on numerous boards and funding committees in the areas of women's health and genomics.

Krina Zondervan

MSc DPhil FRCOG FMedSci

Head of Department, Professor of Reproductive & Genomic Epidemiology, Co-Director Endometriosis CaRe Centre.

Fellow, St Edmund Hall

Research groups

Endometriosis Care

Research

My group works on understanding the pathogenesis of women's health disorders through genomic, molecular, and environmental epidemiological research methods. We are based within the Oxford Endometriosis CaRe Centre, of which I am co-director, and collaborate with a large network of research groups (inter)nationally.

We focus in particular on endometriosis - a common, poorly understood chronic inflammatory condition in women, involving the presence of endometrial-like cells in extra-uterine pelvic sites. The condition causes pain and sub-fertility; is estimated to affect 5-10% of women in their reproductive years (190 million women worldwide and 1.6 million in the UK); has limited diagnostic and treatment options; and has a major impact on health-related quality of life of sufferers and their families that can last beyond menopause.

Heritable factors are involved in endometriosis risk. Identifying which DNA variants underlie this heritability will improve our understanding of pathogenesis and inform treatment development. I co-founded the International Endometriosis Genome Consortium (IEGC) in which we are conducting the largest collaborative genome-wide association studies (GWAS) of endometriosis to date (e.g. Nature Genetics 2011,2012,2023; Nature Communications 2017), the most recent analyses including data from more than 60,000 women with endometriosis.

In addition to continued genetic discovery work, I have led a large global initiative in endometriosis research to develop standardised deep phenotyping tools and sample collection protocols (WERF EPHect); these are implemented so far in more than 60 endometriosis research centres worldwide. In the Endometriosis CaRe centre we are currently using WERF EPHect-compliant data and samples from women attending our centre to explore what biological pathways implicated genetic variants 'signpost', and how findings can aid discovery of novel treatment targets and biomarkers.

To this end, within the Centre we have established a programme of translational research and have established very strong links with industry partners to allow translation of our research findings. This work is made possible through the much appreciated involvement of many women with and without the disease, who contribute information and samples to our studies and through our many collaborations within the WERF EPHect network and beyond.

Funding

The Wellcome Trust; The Medical Research Council; National Institutes of Health USA; World Endometriosis Research Foundation; The European Union; The Bill and Melinda Gates Foundation, and industry partners.

Key publications

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.

Rahmioglu N. et al, (2023), Nat Genet, 55, 423 - 436

Endometriosis.

Zondervan KT. et al, (2020), N Engl J Med, 382, 1244 - 1256

The association between endometriosis and autoimmune diseases: a systematic review and meta-analysis.

Shigesi N. et al, (2019), Hum Reprod Update, 25, 486 - 503

Endometriosis.

Zondervan KT. et al, (2018), Nat Rev Dis Primers, 4

Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.

Sapkota Y. et al, (2017), Nat Commun, 8

Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci.

Rahmioglu N. et al, (2015), Hum Mol Genet, 24, 1185 - 1199

Genome-wide association meta-analysis identifies new endometriosis risk loci

Nyholt DR. et al, (2012), Nature Genetics, 44, 1355 - 1359

Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis.

Painter JN. et al, (2011), Nat Genet, 43, 51 - 54

Recent publications

The value of a non-invasive bladder sensitivity paradigm in chronic pelvic pain.

Coxon L. et al, (2026), Reprod Fertil

Human Endometriotic Lesion-Derived Small Extracellular Vesicles Impair Macrophage Function in the Peritoneal Microenvironment.

Wang Y. et al, (2026), J Extracell Vesicles, 15

Women with chronic pelvic pain can be stratified using multimodal assessment

Demetriou L. et al, (2025), Pain

Longitudinal association between dysmenorrhoea in adolescence and chronic pain in adulthood: a UK population-based study.

Reid-McCann R. et al, (2025), Lancet Child Adolesc Health, 9, 766 - 775

Experiences of women with endometriosis & their partners in India: Findings from a qualitative study.

Rajbangshi PR. et al, (2025), Indian J Med Res, 162, 622 - 630

vailability of region-specific endometriosis care guidance: a global scoping review

Evans D. et al, (2025), Lancet Obstetrics, Gynaecology, and Women's Health, 1, e219 - e231

Endometriosis policy and delivery systems: a comprehensive global scoping review

Gibbons T. et al, (2025), Lancet Obstetrics, Gynaecology, and Women's Health, 1, e232 - e244

systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding.

Wang C-Y. et al, (2025), Commun Med (Lond), 5

Endometriosis: A Review.

As-Sanie S. et al, (2025), JAMA, 334, 64 - 78

The phenotypic and genetic association between endometriosis and immunological diseases.

Shigesi N. et al, (2025), Hum Reprod, 40, 1195 - 1209

las-scale metabolic activities inferred from single-cell and spatial transcriptomics.

Armingol E. et al, (2025)

Consensus on Symptom Selection for Endometriosis Questionnaires: A Modified e-Delphi Study.

Zhu T. et al, (2025), BJOG, 132, 656 - 662

Exploring pre-diagnosis hospital contacts in women with endometriosis using ICD-10: a Danish case-control study.

Melgaard A. et al, (2025), Hum Reprod, 40, 280 - 288

Modelling Endometriosis Using In Vitro and In Vivo Systems.

Black V. et al, (2025), Int J Mol Sci, 26

Circulating inflammatory biomarkers and endometriosis lesion characteristics in the WisE consortium.

Terry KL. et al, (2025), NPJ Womens Health, 3

Translation, cross-cultural adaptation into Brazilian Portuguese and electronic migration of the WERF EPHect endometriosis patient questionnaire.

Anelli GB. et al, (2025), Rev Bras Ginecol Obstet, 47

Exploring the value of a well-established conditioned pain modulation paradigm in women: a Translational Research in Pelvic Pain (TRiPP) study.

Demetriou L. et al, (2025), Front Pain Res (Lausanne), 6

Endometriosis: disease mechanisms and health disparities.

Rahmioglu N. and Zondervan KT., (2024), Bull World Health Organ, 102, 919 - 921

Symptom flares in women with chronic pelvic pain: Questionnaire study within a cohort study (translational research in pelvic pain (TRiPP)).

Coxon L. et al, (2024), BJOG, 131, 1832 - 1840

Enhancing genetic association power in endometriosis through unsupervised clustering of clinical subtypes identified from electronic health records.

Guare LA. et al, (2024), Res Sq

n integrated single-cell reference atlas of the human endometrium.

Marečková M. et al, (2024), Nat Genet, 56, 1925 - 1937

Genome-wide association reveals a locus in neuregulin 3 associated with gabapentin efficacy in women with chronic pelvic pain.

Mackenzie SC. et al, (2024), iScience, 27

The Association between Endometriosis and Immunological diseases

Shigesi N. et al, (2024)

Elevated basophil count is associated with increased risk of endometriosis.

Feng Q. et al, (2024), Reprod Fertil, 5

Enhancing Genetic Association Power in Endometriosis through Unsupervised Clustering of Clinical Subtypes Identified from Electronic Health Records.

Guare L. et al, (2024)

Prevalence, diagnostic delay and economic burden of endometriosis and its impact on quality of life: results from an Eastern Mediterranean population.

Swift B. et al, (2024), Eur J Public Health, 34, 244 - 252

systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding

Wang CY. et al, (2024)

Crimson clues: advancing endometriosis detection and management with novel blood biomarkers.

Gibbons T. et al, (2024), Fertil Steril, 121, 145 - 163

Multicenter evaluation of blood-based biomarkers for the detection of endometriosis and adenomyosis: A prospective non-interventional study.

Burghaus S. et al, (2024), Int J Gynaecol Obstet, 164, 305 - 314

Potential for Diagnosis of Endometriosis Using 99mTc-Maraciclatide.

Gibbons T. et al, (2024), REPRODUCTIVE SCIENCES, 31, 81A - 81A

Large-Scale Multi-Trait Genome-Wide Association of Endometriosis and Uterine Fibroids Reveals Novel Independent and Shared Loci.

Rahmioglu N. et al, (2024), REPRODUCTIVE SCIENCES, 31, 206A - 207A

Long-Term International Dual-Source Endometriosis and Adenomyosis (LIDEA) Registry.

Kiesel L. et al, (2024), REPRODUCTIVE SCIENCES, 31, 281A - 281A

Transcriptomic Phenotyping of Superficial Peritoneal Endometriosis.

Terry KL. et al, (2024), REPRODUCTIVE SCIENCES, 31, 127A - 127A

Untangling Genetic Signature Underlying Endometriosis and Adenomyosis in European and Eastern Mediterranean Populations.

Selcuki NFT. et al, (2024), REPRODUCTIVE SCIENCES, 31, 204A - 204A

Visualisation of Superficial Peritoneal Endometriosis with 99mTc-maraciclatide

Barnett J. et al, (2024), EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 51, S53 - S53

n integrated single-cell reference atlas of the human endometrium

Marečková M. et al, (2023)

Comprehensive quantitative sensory testing shows altered sensory function in women with chronic pelvic pain: results from the Translational Research in Pelvic Pain (TRiPP) Study.

Coxon L. et al, (2023), Pain, 164, 2528 - 2539

Utilization of healthcare prior to endometriosis diagnosis: a Danish case-control study.

Melgaard A. et al, (2023), Hum Reprod, 38, 1910 - 1917

ssociation between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study.

Ohuma EO. et al, (2023), Lancet Haematol, 10, e756 - e766

Global endometrial DNA methylation analysis reveals insights into mQTL regulation and associated endometriosis disease risk and endometrial function.

Mortlock S. et al, (2023), Commun Biol, 6

Women's health: tackle the research funding deficit.

Zondervan KT. et al, (2023), Nature, 619

novel resource to study endometriosis at the single-cell level.

García-Alonso L. et al, (2023), Nat Rev Endocrinol, 19, 256 - 257

Real-world assessment of the patient-centredness of endometriosis care: European countries benchmarked by patients.

Eaf D. et al, (2023), Best Pract Res Clin Obstet Gynaecol, 87

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.

Rahmioglu N. et al, (2023), Nat Genet, 55, 423 - 436

Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata.

Sliz E. et al, (2023), Nat Commun, 14

Clinical profiling of specific diagnostic subgroups of women with chronic pelvic pain.

Demetriou L. et al, (2023), Front Reprod Health, 5

Predictors and trends of Caesarean section and breastfeeding in the Eastern Mediterranean region: Data from the cross-sectional Cyprus Women's Health Research (COHERE) Initiative.

Swift B. et al, (2023), PLoS One, 18

Genetics and genomics of endometriosis☆

Giudice LC. et al, (2023), 599 - 631

Multi-omics Approach at the Tissue and Single-Cell Level Provides New Insight into the Pathomechanisms of Uterine Fibroids and Associated Heavy Menstrual Bleeding

Philpott M. et al, (2023), REPRODUCTIVE SCIENCES, 30, 207A - 208A

Chapter 23 Genetics and genomics of endometriosis☆

Giudice LC. et al, (2023), 599 - 631

Global Endometrial DNA Multi-omics Analysis Reveals Insights into mQTL Regulation and Associated Endometriosis Disease Risk

Mortlock S. et al, (2022)

Stressful experiences impact clinical symptoms in people with endometriosis

Demetriou L. et al, (2022), Reproduction and Fertility

Clinical profiling of specific diagnostic subgroups of women with chronic pelvic pain

Demetriou L. et al, (2022)

Correction: Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.

Gallagher CS. et al, (2022), Nat Commun, 13

Correction: Obesity and risk of female reproductive conditions: A Mendelian randomisation study.

Venkatesh SS. et al, (2022), PLoS Med, 19

The Cyprus Women's Health Research (COHERE) initiative: normative data from the SF-36v2 questionnaire for reproductive aged women from the Eastern Mediterranean.

Swift B. et al, (2022), Qual Life Res, 31, 2011 - 2022

P-313 The Cyprus women’s health research (COHERE) initiative: estimating the prevalence, symptomatology, associated risk factors and economic burden of endometriosis in an Eastern Mediterranean population

Swift B. et al, (2022), Human Reproduction, 37

Genome-wide association analysis and replication in 810,625 individuals with varicose veins.

Ahmed W-U-R. et al, (2022), Nat Commun, 13

Endometriosis Classification Systems: An International Survey to Map Current Knowledge and Uptake.

Zondervan KT. et al, (2022), J Minim Invasive Gynecol, 29, 716 - 725.e1

Deep phenotyping of women with endometriosis-associated pain and bladder pain syndrome: the TRiPP (Translational Research in Pelvic Pain) study protocol

Demetriou L. et al, (2022)

Endometriosis classification systems: an international survey to map current knowledge and uptake.

International Working Group of AAGL, ESGE, ESHRE and WES . et al, (2022), Facts Views Vis Obgyn, 14, 5 - 15

Endometriosis classification systems: an international survey to map current knowledge and uptake

Zondervan KT. et al, (2022), Facts Views and Vision in Obgyn, 14, 5 - 15

Obesity and risk of female reproductive conditions: A Mendelian randomisation study.

Venkatesh SS. et al, (2022), PLoS Med, 19

Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways.

Adewuyi EO. et al, (2022), Hum Reprod, 37, 366 - 383

[Analysis of the factors contributing to endometriosis in China and UK].

Nie W. et al, (2022), Nan Fang Yi Ke Da Xue Xue Bao, 42, 137 - 142

Shared genetic architecture of hernias: A genome-wide association study with multivariable meta-analysis of multiple hernia phenotypes.

Ahmed WU-R. et al, (2022), PLoS One, 17

Endometriosis classification systems: an international survey to map current knowledge and uptake.

International Working Group of AAGL, ESGE, ESHRE and WES . et al, (2022), Hum Reprod Open, 2022

Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.

Hawe JS. et al, (2022), Nat Genet, 54, 18 - 29

The role of endometrial B cells in normal endometrium and benign female reproductive pathologies: a systematic review.

Shen M. et al, (2022), Hum Reprod Open, 2022

Pathogenesis of Endometriosis: Genetics

Rahmioglu N. and Zondervan KT., (2022), 75 - 84

Towards an Understanding of the Pathomechanisms of Uterine Fibroids and Associated Heavy Menstrual Bleeding Using Systems Biology Approaches

Wang C-Y. et al, (2022), REPRODUCTIVE SCIENCES, 29, 204 - 204

Single-Cell Atlas of the Leiomyoma Vascular Capsule Reveals Activation of Endothelial and Immune Cells

Philpott M. et al, (2022), REPRODUCTIVE SCIENCES, 29, 205 - 205

The Cyprus women's health research (COHERE) initiative: estimating the prevalence, symptomatology, associated risk factors and economic burden of endometriosis in an Eastern Mediterranean population

Swift B. et al, (2022), HUMAN REPRODUCTION, 37

Transcriptomic Profiling of Endometrium and Subcutaneous Adipose Tissues in Association with Endometriosis

Ndungu A. et al, (2022), REPRODUCTIVE SCIENCES, 29, 52 - 52

Endometriosis classification systems: an international survey to map current knowledge and uptake

Zondervan KT. et al, (2022), FACTS VIEWS AND VISION IN OBGYN, 14, 5 - 15

Genetics of endometriosis

Zondervan K., (2022), EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 273, E12 - E12

n International Terminology for Endometriosis, 2021.

International Working Group of AAGL, ESGE, ESHRE and WES . et al, (2021), Facts Views Vis Obgyn, 13, 295 - 304

Endometriosis classification, staging and reporting systems: a review on the road to a universally accepted endometriosis classification.

International Working Group of AAGL, ESGE, ESHRE and WES . et al, (2021), Facts Views Vis Obgyn, 13, 305 - 330

Endometriosis Classification, Staging and Reporting Systems: A Review on the Road to a Universally Accepted Endometriosis Classification.

Vermeulen N. et al, (2021), J Minim Invasive Gynecol, 28, 1822 - 1848

n International Terminology for Endometriosis, 2021.

International working group of AAGL, ESGE, ESHRE and WES . et al, (2021), J Minim Invasive Gynecol, 28, 1849 - 1859

Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus.

Kho PF. et al, (2021), Hum Genet, 140, 1353 - 1365

Stressful experiences impact on pain, fatigue and mental health in people with endometriosis: a questionnaire study during the COVID-19 pandemic

Demetriou L. et al, (2021)

The role of obesity in female reproductive conditions: A Mendelian Randomisation study

Venkatesh SS. et al, (2021)

ssociation Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study.

Villar J. et al, (2021), JAMA Pediatr, 175, 483 - 493

Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality.

Adewuyi EO. et al, (2021), Hum Genet, 140, 529 - 552

Preterm birth phenotypes have differential morbidity, growth and neurodevelopment at age 2: the INTERBIO-21st Newborn

KENNEDY S. et al, (2021), JAMA Pediatrics

Endometriosis and cancer: a systematic review and meta-analysis.

Kvaskoff M. et al, (2021), Hum Reprod Update, 27, 393 - 420

Endometriosis classification, staging and reporting systems: a review on the road to a universally accepted endometriosis classification.

International working group of AAGL, ESGE, ESHRE and WES . et al, (2021), Hum Reprod Open, 2021

Impact of Endometriosis in Women of Arab Ancestry on: Health-Related Quality of Life, Work Productivity, and Diagnostic Delay.

Mousa M. et al, (2021), Front Glob Womens Health, 2

Protocol for the Cultural Translation and Adaptation of the World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project Endometriosis Participant Questionnaire (EPHect).

Mis C. et al, (2021), Front Glob Womens Health, 2

Genome-Wide Association Analysis and Replication In 810,625 Individuals Identifies Novel Therapeutic Targets for Varicose Veins

Ahmed WULR. et al, (2021), BRITISH JOURNAL OF SURGERY, 108

Obesity and Risk of Female Reproductive Conditions: A Mendelian Randomisation Study

Venkatesh SS. et al, (2021), GENETIC EPIDEMIOLOGY, 45, 796 - 796

Genome-Wide Association Analysis In 401,583 Individuals Identifies Novel Therapeutic Targets for Haemorrhoids

Ahmed WULR. et al, (2021), BRITISH JOURNAL OF SURGERY, 108

Discovery of Novel Molecular Mechanisms Underlying the Pathophysiology of Uterine Fibroids and Associated Heavy Menstrual Bleeding

Wang C-Y. et al, (2021), REPRODUCTIVE SCIENCES, 28, 133A - 133A

Genome-Wide Association Analysis In 401,583 Individuals Identifies Novel Therapeutic Targets for Haemorrhoids

Ahmed WULR. et al, (2021), BRITISH JOURNAL OF SURGERY, 108

commentary on the need for support with mental as well as physical health for people with endometriosis during the COVID-19 pandemic and beyond.

Demetriou L. et al, (2020)

The genetic architecture of sporadic and multiple consecutive miscarriage.

Laisk T. et al, (2020), Nat Commun, 11

Gabapentin for chronic pelvic pain in women (GaPP2): a multicentre, randomised, double-blind, placebo-controlled trial.

Horne AW. et al, (2020), Lancet, 396, 909 - 917

Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits.

Glastonbury CA. et al, (2020), PLoS Comput Biol, 16

Phenotyping women with endometriosis according to widespread pain: a replication study in the UK Biobank

Perro D. et al, (2020), BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 127, E68 - E69

Neuroimaging reveals that in endometriosis, neuropathic pain is associated with provoked brainstem activity in an area with no resting connectivity

Coxon L. et al, (2020), BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 127, E56 - E57

Endometriosis. Reply.

Becker CM. et al, (2020), N Engl J Med, 383

Genome-wide association analysis and replication in 810,625 individuals identifies novel therapeutic targets for varicose veins

Ahmed W-U-R. et al, (2020), BioRxiv

Endometriosis.

Zondervan KT. et al, (2020), N Engl J Med, 382, 1244 - 1256

Correction: Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions.

Thézénas M-L. et al, (2020), Sci Rep, 10

Discovery of Novel Molecular Mechanisms Underlying the Pathophysiology of Uterine Fibroids and Associated Heavy Menstrual Bleeding.

Wang C-Y. et al, (2020), REPRODUCTIVE SCIENCES, 27, 301A - 301A

Neuropeptide S Receptor 1 is a Novel Non-Hormonal Treatment Target in Endometriosis.

Tapmeier TT. et al, (2020), REPRODUCTIVE SCIENCES, 27, 130A - 130A

Investigation of Symptomatology, Risk Factors and Comorbidities Associated with Endometriosis in the Middle East - A Meta-Analysis Plus Study of 2,750 Arab-Ancestry Women.

Mousa M. et al, (2020), REPRODUCTIVE SCIENCES, 27, 219A - 219A

The Effect of Peritoneal Fluid-Derived Exosomes From Endometriosis Patients on Mesothelial Cells.

Li KY. et al, (2020), REPRODUCTIVE SCIENCES, 27, 300A - 301A

Protocol for a longitudinal, prospective cohort study investigating the biology of uterine fibroids and endometriosis, and patients' quality of life: the FENOX study.

Tapmeier TT. et al, (2020), BMJ Open, 10

Mass cytometry analysis reveals a distinct immune environment in peritoneal fluid in endometriosis: a characterisation study.

Guo M. et al, (2020), BMC Med, 18

Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.

Gallagher CS. et al, (2019), Nat Commun, 10

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Turcot V. et al, (2019), Nat Genet, 51, 1191 - 1192

Role of FN1 and GREB1 gene polymorphisms in endometriosis.

Matalliotaki C. et al, (2019), Mol Med Rep, 20, 111 - 116

Do women with endometriosis have an increased risk for immunological diseases? A systematic review of the literature and study of 273,404 women from UK Biobank

Shigesi N. et al, (2019), HUMAN REPRODUCTION, 34, 40 - 41

Machine Learning based histology phenotyping to investigate epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits

Glastonbury CA. et al, (2019)

lternative angiogenesis mechanisms in uterine fibroids related to heavy menstrual bleeding

Subramaniam KS. et al, (2019), BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 126, E125 - E126

Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis

Allen RJ. et al, (2019)

Cyprus Women's Health Research (COHERE) initiative: determining the relative burden of women's health conditions and related co-morbidities in an Eastern Mediterranean population.

Hocaoglu MB. et al, (2019), BMC Womens Health, 19

Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol.

Kennedy SH. et al, (2019), Gates open research, 2, 49 - 49

Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21st Newborn Case-Control Study protocol

(2019), Gates Open Research

Large-scale meta-analysis highlights the hypothalamic-pituitary-gonadal axis in the genetic regulation of menstrual cycle length.

Laisk T. et al, (2018), Hum Mol Genet, 27, 4323 - 4332

Large-scale genome-wide association meta-analysis of endometriosis reveals 13 novel loci and genetically-associated comorbidity with other pain conditions

Rahmioglu N. et al, (2018), BioRXiv

GWAS meta-analysis highlights the hypothalamic-pituitary-gonadal axis (HPG axis) in the genetic regulation of menstrual cycle length

Laisk T. et al, (2018), BioRxiv

Genome-wide association analysis identifies 27 novel loci associated with uterine leiomyomata revealing common genetic origins with endometriosis

Gallagher C. et al, (2018), BioRxiv

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Turcot V. et al, (2018), Nat Genet, 50, 766 - 767

Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses.

Painter JN. et al, (2018), Cancer Med, 7, 1978 - 1987

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Turcot V. et al, (2018), Nat Genet, 50, 765 - 766

The role of IL‑16 gene polymorphisms in endometriosis.

Matalliotakis M. et al, (2018), Int J Mol Med, 41, 1469 - 1476

Oxidative Stress in Endometriosis Induces IL-8 Release Directly via 4-HNE.

Elger BJ. et al, (2018), REPRODUCTIVE SCIENCES, 25, 219A - 219A

Proteomic and Transcriptomic Analysis of Oxidative Stress, Lipid Peroxidation and Iron Uptake Signatures in Endometriotic Lesions.

Elger B. et al, (2018), REPRODUCTIVE SCIENCES, 25, 289A - 290A

Large-Scale Data Analysis on Endometriosis from the UK Biobank Reveals Novel Genetic Loci.

Rahmioglu N. et al, (2018), REPRODUCTIVE SCIENCES, 25, 61A - 62A

Peripheral Basophil Count is Increased in Patients with Endometriosis.

Feng Q. et al, (2018), REPRODUCTIVE SCIENCES, 25, 218A - 218A

Quantitative Characterization by Mass Cytometry Reveals a Complex Immune Environment and Activation Pattern in the Peritoneal Fluid of Endometriosis Patients

Guo M. et al, (2018), REPRODUCTIVE SCIENCES, 25, 147A - 147A

The Medium-Chain Free Fatty Acid Receptor GPR84 in Endometriosis Associated Pain.

Sacher F. et al, (2018), REPRODUCTIVE SCIENCES, 25, 290A - 290A

The miRNA Mirage: How Close Are We to Finding a Non-Invasive Diagnostic Biomarker in Endometriosis? A Systematic Review.

Agrawal S. et al, (2018), Int J Mol Sci, 19

Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol.

Kennedy SH. et al, (2018), Gates Open Res, 2

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Turcot V. et al, (2018), Nat Genet, 50, 26 - 41

DNA methylation changes in endometrium and correlation with gene expression during the transition from pre-receptive to receptive phase.

Kukushkina V. et al, (2017), Sci Rep, 7

Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.

Sapkota Y. et al, (2017), Nat Commun, 8

ssociation Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.

Telomeres Mendelian Randomization Collaboration . et al, (2017), JAMA Oncol, 3, 636 - 651

Genome-wide genetic analyses highlight mitogen-activated protein kinase (MAPK) signaling in the pathogenesis of endometriosis.

Uimari O. et al, (2017), Hum Reprod, 32, 780 - 793

Scientific Program Schedule 64th Annual Scientific Meeting.

(2017), Reprod Sci, 24, A2 - A51

Large-Scale Integrated Genome-Wide RNA Sequencing, miRNA Array, and Genomic Analyses to Unravel the Functionality of Genome-Wide Association Results in Endometriosis.

Rahmioglu N. et al, (2017), REPRODUCTIVE SCIENCES, 24, 205A - 206A

Variability of genome-wide DNA methylation and mRNA expression profiles in reproductive and endocrine disease related tissues.

Rahmioglu N. et al, (2017), Epigenetics, 12, 897 - 908

Population based Northern Finland Birth Cohort 1966 study shows serum lipids and metabolic syndrome to have association with an increased risk of uterine fibroids

Uimari O. et al, (2016), HUMAN REPRODUCTION, 31, 461 - 462

Genome-wide DNA methylation and mRNA expression profiling in eutopic endometrium, disease tissue and fat: implications for endometriosis research

Rahmioglu N. et al, (2016), HUMAN REPRODUCTION, 31, 9 - 10

Leveraging Population-Based Cohorts to Understand the Genetic Aetiology of Benign Gynaecological Disorders and Their Overlap: The UK Biobank.

Ferreira T. et al, (2016), REPRODUCTIVE SCIENCES, 23, 84A - 85A

Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants.

Allum F. et al, (2015), Nat Commun, 6

Variability of Genome-Wide Gene Expression and DNA Methylation Profiles Across Tissue Samples From Women With and Without Endometriosis

Rahmioglu N. et al, (2015), REPRODUCTIVE SCIENCES, 22, 209A - 209A

Genome-wide pathway analysis highlights the role of Wnt signaling in endometriosis

Uimari O. et al, (2015), HUMAN REPRODUCTION, 30, 283 - 284

World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: IV. Tissue collection, processing, and storage in endometriosis research.

Fassbender A. et al, (2014), Fertil Steril, 102, 1244 - 1253

World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: III. Fluid biospecimen collection, processing, and storage in endometriosis research.

Rahmioglu N. et al, (2014), Fertil Steril, 102, 1233 - 1243

World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: I. Surgical phenotype data collection in endometriosis research.

Becker CM. et al, (2014), Fertil Steril, 102, 1213 - 1222

Distinct developmental profile of lower-body adipose tissue defines resistance against obesity-associated metabolic complications.

Pinnick KE. et al, (2014), Diabetes, 63, 3785 - 3797

World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: II. Clinical and covariate phenotype data collection in endometriosis research.

Vitonis AF. et al, (2014), Fertil Steril, 102, 1223 - 1232

Multi-ethnic fine-mapping of 14 central adiposity loci.

Liu C-T. et al, (2014), Hum Mol Genet, 23, 4738 - 4744

Common variants in the CYP2C19 gene are associated with susceptibility to endometriosis.

Painter JN. et al, (2014), Fertil Steril, 102, 496 - 502.e5

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.

Ng MCY. et al, (2014), PLoS Genet, 10

Quality control and conduct of genome-wide association meta-analyses.

Winkler TW. et al, (2014), Nat Protoc, 9, 1192 - 1212

Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets.

Rahmioglu N. et al, (2014), Hum Reprod Update, 20, 702 - 716

Meta-Analysis of GWAS Signals for Endometriosis to Date: Consistency and Heterogeneity across Eight Datasets Totaling More Than 11,000 Cases and 32,000 Controls

Rahmioglu N. et al, (2014), REPRODUCTIVE SCIENCES, 21, 106A - 107A

Fine Mapping Genomic Regions Associated with Endometriosis Risk

Montgomery GW. et al, (2014), REPRODUCTIVE SCIENCES, 21, 312A - 312A

Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements

Grundberg E. et al, (2013), The American Journal of Human Genetics, 93, 1158 - 1158

Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements.

Grundberg E. et al, (2013), Am J Hum Genet, 93, 876 - 890

Gene expression changes with age in skin, adipose tissue, blood and brain.

Glass D. et al, (2013), Genome Biol, 14

Session 06: Endometriosis

Carvalho LF. et al, (2013), Human Reproduction, 28, i12 - i14

Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.

Saxena R. et al, (2013), Diabetes, 62, 1746 - 1755

bstract 3182: A GWAS-based cross-disease approach suggests genes predisposing to risk of endometriosis and endometrial cancer.

Painter JN. et al, (2013), Cancer Research, 73, 3182 - 3182

Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis.

Lee SH. et al, (2013), Hum Mol Genet, 22, 832 - 841

No evidence for genetic association with the let-7 microRNA-binding site or other common KRAS variants in risk of endometriosis.

Luong HTT. et al, (2012), Hum Reprod, 27, 3616 - 3621

Developing symptom-based predictive models of endometriosis as a clinical screening tool: results from a multicenter study.

Nnoaham KE. et al, (2012), Fertil Steril, 98, 692 - 701.e5

genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

Manning AK. et al, (2012), Nat Genet, 44, 659 - 669

Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population.

Bell JT. et al, (2012), PLoS Genet, 8

Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.

Min JL. et al, (2012), PLoS Genet, 8

Is early age at menarche a risk factor for endometriosis? A systematic review and meta-analysis of case-control studies

Nnoaham KE. et al, (2012), Fertility and Sterility, 98

Developing symptom-based predictive models of endometriosis as a clinical screening tool: Results from a multicenter study

Nnoaham KE. et al, (2012), Fertility and Sterility, 98

Common genetic variants underlie endometriosis and obesity-related traits

Rahmioglu N. et al, (2012), HUMAN REPRODUCTION, 27

Identifying the Genes Associated with Endometriosis Risk on Chromosomes 1 and 7

Montgomery GW. et al, (2012), REPRODUCTIVE SCIENCES, 19, 141A - 141A

Effect of empirical use of hormonal contraception on pain and quality of life in symptomatic women with endometriosis: an international multi-centre study

Stavroulis A. et al, (2012), HUMAN REPRODUCTION, 27

The ENDOCARE questionnaire (ECQ): a valid and reliable instrument to measure the patient-centeredness of endometriosis care in Europe.

Dancet EAF. et al, (2011), Hum Reprod, 26, 2988 - 2999

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution (Nature Genetics (2010) 42 (949-960))

Heid IM. et al, (2011), Nature Genetics, 43

Coding regions of INHBA, SFRP4 and HOXA10 are not implicated in familial endometriosis linked to chromosome 7p13-15.

Lin J. et al, (2011), Mol Hum Reprod, 17, 605 - 611

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

Strawbridge RJ. et al, (2011), Diabetes, 60, 2624 - 2634

High-density fine-mapping of a chromosome 10q26 linkage peak suggests association between endometriosis and variants close to CYP2C19.

Painter JN. et al, (2011), Fertil Steril, 95, 2236 - 2240

Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes.

Small KS. et al, (2011), Nat Genet, 43, 561 - 564

High-density fine-mapping of a chromosome 10q26 linkage peak suggests association between endometriosis and variants close to CYP2C19

Painter JN. et al, (2011), Fertility and Sterility, 95, 2236 - 2240

The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits.

Min JL. et al, (2011), PLoS One, 6

Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis.

Painter JN. et al, (2011), Nat Genet, 43, 51 - 54

MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven.

Rantalainen M. et al, (2011), PLoS One, 6

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

Heid IM. et al, (2011), Nat Genet, 43

Genome-Wide Association Study of Endometriosis Shows Differential Etiology by Stage and Identifies a Locus at 7p15.2 Associated with the Development of Moderate-Severe Disease

Zondervan KT. et al, (2011), REPRODUCTIVE SCIENCES, 18, 197A - 197A

Clinical Symptoms as Predictors of a Surgical Diagnosis of Endometriosis

Zondervan KT. et al, (2011), REPRODUCTIVE SCIENCES, 18, 275A - 275A

Chapter 3 Genetic Association Study Design

Zondervan KT., (2011), 25 - 48

simple and fast two-locus quality control test to detect false positives due to batch effects in genome-wide association studies.

Lee SH. et al, (2010), Genet Epidemiol, 34, 854 - 862

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

Heid IM. et al, (2010), Nat Genet, 42, 949 - 960

Optimizing the power of genome-wide association studies by using publicly available reference samples to expand the control group.

Zhuang JJ. et al, (2010), Genet Epidemiol, 34, 319 - 326

Micro-ribonucleic acid expression profiling and expression quantitative trait loci analysis in human gluteal and abdominal adipose tissue

Rantalainen M. et al, (2010), DIABETOLOGIA, 53

Multi-Centre Studies of the Global Impact of Endometriosis and the Predictive Value of Associated Symptoms.

Nnoaham KE. et al, (2010), REPRODUCTIVE SCIENCES, 17, 95A - 96A

Genome-wide Association Study of Endometriosis Shows Differential Etiology by Stage and Identifies a Locus at 7p15.2 Associated with the Development of Moderate-severe Disease

Zondervan KT. et al, (2010), GENETIC EPIDEMIOLOGY, 34, 976 - 977

135. GENOME-WIDE ASSOCIATION STUDY IDENTIFIES A LOCUS AT 7p15.2 ASSOCIATED WITH THE DEVELOPMENT OF MODERATE - SEVERE ENDOMETRIOSIS

Montgomery GW. et al, (2010), Reproduction Fertility and Development, 22

Optimising the power of genome-wide association studies by using publicly available reference samples to expand the control group

Zhuang JJ. et al, (2009), Gen.Epidem.

Optimising the power of genome-wide association studies by using publicly available reference samples to expand the controls group

Zhuang JJ. et al, (2009), ANNALS OF HUMAN GENETICS, 73, 661 - 661

The endothelial nitric oxide synthase Glu298Asp polymorphism is not a risk factor for endometriosis in south Indian women.

Bhanoori M. et al, (2008), Eur J Obstet Gynecol Reprod Biol, 139, 53 - 58

Genetic variation and endometriosis risk

Montgomery GW. et al, (2008), 37 - 48

The exon 1-8C/G SNP in the PSMA6 gene contributes only a small amount to the burden of myocardial infarction in 6946 cases and 2720 controls from a United Kingdom population.

Bennett DA. et al, (2008), Eur J Hum Genet, 16, 480 - 486

Significant evidence of one or more susceptibility loci for endometriosis with near-Mendelian inheritance on chromosome 7p13-15.

Zondervan KT. et al, (2007), Hum Reprod, 22, 717 - 728

Vascular endothelial growth factor +936 C/T polymorphism is associated with an increased risk of endometriosis in a Japanese population.

Ikuhashi Y. et al, (2007), Acta Obstet Gynecol Scand, 86, 1352 - 1358

Chronic pelvic pain in women in New Zealand: comparative well-being, comorbidity, and impact on work and other activities.

Grace V. and Zondervan K., (2006), Health Care Women Int, 27, 585 - 599

Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study.

Clarke R. et al, (2006), PLoS Genet, 2

Prevalence and incidence of adults consulting for shoulder conditions in UK primary care; patterns of diagnosis and referral.

Linsell L. et al, (2006), Rheumatology (Oxford), 45, 215 - 221

Chronic pelvic pain in women in New Zealand: comparative well-being, comorbidity, and impact on work and other activities

Grace VM. and Zondervan KT., (2006), Health.Care.Women.Int., 27, 585 - 599

Does the disease endometriosis exist - research implications

Zondervan K., (2006), HUMAN REPRODUCTION, 21, I1 - I1

ssessment of the Lequesne index of severity for osteoarthritis of the hip in an elderly population.

Dawson J. et al, (2005), Osteoarthritis Cartilage, 13, 854 - 860

The vascular endothelial growth factor (VEGF) +405G>C 5'-untranslated region polymorphism and increased risk of endometriosis in South Indian women: a case control study.

Bhanoori M. et al, (2005), Hum Reprod, 20, 1844 - 1849

Prospective study of elderly people comparing treatments following first primary care consultation for a symptomatic hip or knee.

Linsell L. et al, (2005), Fam Pract, 22, 118 - 125

First evidence that one or more rare genetic polymorphisms with high penetrance may be involved in the aetiology of endometriosis

Zondervan KT. et al, (2005), GENETIC EPIDEMIOLOGY, 29, 292 - 292

Oral contraceptives and cervical cancer--further findings from the Oxford Family Planning Association contraceptive study.

Zondervan KT. et al, (1996), Br J Cancer, 73, 1291 - 1297

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Krina Zondervan

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