Andy Greenfield
BA, MA, PhD
Honorary Research Lecturer
- Andy was on the examination board for the MSc in Clinical Embryology for 5 years and was Chair of Examiners from 2022 to 2024. Andy continues to teach on the course, having expertise in sex determination, mitochondrial donation and the ethics of assisted reproduction.
Short biography
Andy led a programme of research in developmental genetics at the MRC’s Mammalian Genetics Unit at Harwell for 25 years. His research focussed on the contribution that genetic variation makes to disease processes during development, with a focus on sex determination and related embryonic and fetal conditions.
Andy has significant experience and expertise in policy, regulation and ethical governance in the area of emerging technologies in the life sciences. From 2009 to 2018, he was a board member of the Human Fertilisation & Embryology Authority (HFEA) and chaired its Licence Committee for several years. In 2014 and 2016, he chaired two expert panels that considered the safety and efficacy of mitochondrial replacement techniques (MRT) - also known as mitochondrial donation. He was a member of the Nuffield Council on Bioethics (NCOB) from 2014 to 2020 and in 2016 chaired its working group that considered the ethics of genome editing in a variety of contexts. He has also contributed to a 2024 NCOB report on the governance of human stem cell-based embryo models. In 2019-2020, he was a member of the National Academies International Commission that considered possible clinical uses of heritable human genome editing and also a member of the ISSCR working party that updated its guidelines on heritable genome editing and MRT. In 2019, he was awarded the Patrick Steptoe Medal of the British Fertility Society in recognition of his contributions to reproductive medicine.
Since 2020, he has been a member of the Regulatory Horizons Council, an expert committee that advises the UK Government on the regulation of emerging technologies in diverse sectors. He is a member of the Board of the Human Tissue Authority (since 2022). He also chairs a subcommittee of the Food Standard Agency’s advisory committee, the ACNFP, charged with developing an assessment framework for precision bred (genome-edited) organisms for food and feed purposes. He is a Fellow of the Royal Society of Biology.
Recent publications
Preclinical research (on rare diseases): we need to talk about health equity.
Journal article
Greenfield A., (2025), Mamm Genome, 36, 347 - 353
Gonadal sex reversal at single-cell resolution in Znrf3-deficient mice.
Journal article
Kay RGG. et al, (2024), Development, 151
SEC31A may be associated with pituitary hormone deficiency and gonadal dysgenesis.
Journal article
Tobias ES. et al, (2024), Endocrine, 84, 345 - 349
Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad.
Journal article
Mayère C. et al, (2022), Sci Adv, 8
Gadd45g is required for timely Sry expression independently of RSPO1 activity.
Journal article
Warr N. et al, (2022), Reproduction, 163, 333 - 340
Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad
Preprint
Mayère C. et al, (2021)
est of WNT/β-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries.
Journal article
Le Rolle M. et al, (2021), Proc Natl Acad Sci U S A, 118
25th ANNIVERSARY OF CLONING BY SOMATIC-CELL NUCLEAR TRANSFER: Cloning, mitochondrial replacement and genome editing: 25 years of ethical debate since Dolly.
Journal article
Greenfield A., (2021), Reproduction, 162, F69 - F78
Protection Against XY Gonadal Sex Reversal by a Variant Region on Mouse Chromosome 13.
Journal article
Livermore C. et al, (2020), Genetics, 214, 467 - 477
Pathogenic variants in the DEAH-box RNA helicase DHX37 are a frequent cause of 46,XY gonadal dysgenesis and 46,XY testicular regression syndrome.
Journal article
McElreavey K. et al, (2020), Genet Med, 22, 150 - 159
Male mice lacking ADAMTS-16 are fertile but exhibit testes of reduced weight.
Journal article
Livermore C. et al, (2019), Sci Rep, 9
ddressing gaps in care of people with conditions affecting sex development and maturation.
Journal article
Hiort O. et al, (2019), Nat Rev Endocrinol, 15, 615 - 622
Dissecting Cell Lineage Specification and Sex Fate Determination in Gonadal Somatic Cells Using Single-Cell Transcriptomics.
Journal article
Stévant I. et al, (2019), Cell Rep, 26, 3272 - 3283.e3
Fearful old world? A commentary on the Second International Summit on human genome editing.
Journal article
Greenfield A., (2019), Mamm Genome, 30, 1 - 4
Characterizing the bipotential mammalian gonad.
Journal article
Nef S. et al, (2019), Curr Top Dev Biol, 134, 167 - 194