Dr Thomas Theodor Tapmeier
I have always been fascinated by the way the human body is able to defend itself against harm and disease and therefore went to study Humanbiologie at the Philipps-Universitaet Marburg in my native country, Germany, with a focus on immunology. After a brief spell as a carer for an ill family member, I worked at the Johann Wolfgang von Goethe-Universitaet Frankfurt am Main in stem cell research before winning a scholarship to take up PhD studies in transplantation immunology at the MRC Centre for Transplantation, at King's College London in the UK. We showed that a class of immune cells, the CD4+ T cells, are important in the development of renal fibrosis within the context of chronic kidney disease. Similar mechanisms are thought to be at play in cancer, and I went to Oxford next to study immune cells in cancer and metastasis, here focusing on macrophages which work in concert with T cells. While a lot is known in this area, the role of immune cells in endometriosis is far less well described, and I hope to be able to bring my experience to bear as we in the Nuffield Department of Obstetrics and Gynaecology, and the EndoCaRe Centre, endeavour to understand this terrible condition, and find new ways of treatment.
The miRNA Mirage: How Close Are We to Finding a Non-Invasive Diagnostic Biomarker in Endometriosis? A Systematic Review.
Agrawal S. et al, (2018), International Journal of Molecular Sciences, 19
Is pale the way to go to understand adenomyosis?
Tapmeier TT. and Becker CM., (2015), Fertil Steril, 104
The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions.
Tapmeier TT. et al, (2015), Proc Natl Acad Sci U S A, 112, 9710 - 9715
Motion Correction of Intravital Microscopy of Preclinical Lung Tumour Imaging Using Multichannel Structural Image Descriptor.
Papiez BW. et al, (2014), WBIR, 8545, 164 - 173
The response of infiltrating and resident macrophages to melanoma challenge in the mouse lung: Involvement of the CC-chemokine axis in the recruitment of pro-tumoral macrophages.
Tapmeier TT. et al, (2013), CANCER RESEARCH, 73