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Ana Kisovar
MD
Postdoctoral Research Assistant in Bioinformatics / Immunology
I am a medical doctor from Slovenia. After graduating from the Faculty of Medicine in Ljubljana (Slovenia) and the University of Heidelberg (Germany) in 2019, I completed my clinical training and worked as a medical writer in Zurich (Switzerland) before starting my DPhil at the Nuffield Department of Women's and Reproductive Health in 2020.
Under the supervision of Dr. Jen Southcombe, Assoc. Prof. Ingrid Granne, and Assoc. Prof. Christian Becker, my research delved into the immunological background of adverse reproductive outcomes, including recurrent pregnancy loss and endometriosis-associated subfertility. Endometriosis, defined as the growth of endometrium-like tissue outside the uterus, affects 1 in 10 women, of whom 35–50% suffer from subfertility. Recurrent pregnancy loss is defined as the loss of two or more subsequent clinically recognized pregnancies before week 24 and affects 1 in 50 pregnant women. In my thesis, I investigated the role of CD8+ T cells, the major T cell population, constituting 25–35% of all endometrial leukocytes.
Drawing on my clinical and research expertise, I am currently undertaking single-cell RNA sequencing to better define and understand endometrial adaptive immunity during the window of embryo implantation. This will hopefully lead to new ways to treat recurrent pregnancy loss and endometriosis-associated subfertility.
Recent publications
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The Role of CD8+ T Cells in Endometriosis: A Systematic Review
Journal article
Kisovar A. et al, (2023), Frontiers in Immunology
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The role of CD8+ T cells in endometriosis: a systematic review
Other
Kisovar A. et al, (2022)
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The Role of Endometrial B Cells in Normal Endometrium and in Benign Female Reproductive Pathologies: a Systematic Review
Journal article
SOUTHCOMBE J. et al, (2021), Human Reproduction Open
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Eutopic endometrial CD8+ T cells in endometriosis-associated subfertility
Poster
Kisovar A. et al, (2021)
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Oncofertility Approach in Females With Leukemia From the Reproductive Perspective
Journal article
Kisovar A. and Bokal EV., (2020), healthbook TIMES Oncology Hematology, 10 - 17