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PROJECT TITLE

Translational Research in Pelvic Pain (TRiPP): Endometriosis and Bladder Pain Syndrome Projects

SUPERVISORS

Prof Katy Vincent

Prof Krina Zondervan


DESCRIPTION OF PROJECT

Although incredibly common conditions, very little is understood about how pain is generated or maintained in endometriosis-associated pain or bladder pain syndrome. Current treatments target the pelvis/bladder and are at best only partially successful, with relatively high recurrence rates. TRiPP is a subproject of IMI-PainCare (https://www.imi-paincare.eu) funded by the Innovative Medicines Initiative 2 Joint Undertaking. This project aims to consider these conditions in the context of the multisystem dysfunction known to occur in other chronic pain conditions rather than just as end-organ pathologies. We are therefore collecting large volumes of epidemiological, omics, pain phenotyping, psychological, endocrine and functional and structural neuroimaging data on women with endometriosis-associated pain, bladder pain syndrome and pain free controls. DPhil projects can be targeted to specific areas of interest to more deeply analyse subgroups of this data.

TRAINING OPPORTUNITIES

We are a multi-disciplinary group based at the Endometriosis CaRe Cenre (Nuffield Department for Women’s and Reproductive Health) and close collaborations in Oxford with the Wellcome Centre for Human Genetics, the Wellcome Centre for Integrative NeuroImaging and the Kennedy Centre for Rheumatology. Partners in TRiPP are spread throughout Europe and include a US partner (Boston), with the potential to work closely with Industry during the project. Projects analysing this data would allow interested students to develop complementary skills in areas including epidemiology, advanced omics analyses, neuroimaging and cognitive neuroscience. Including the opportunity to complete the FMRIB graduate program if neuroimaging was a component of the project.