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The Oxford Safer Pregnancy Alliance (OSPREA) is a team of doctors, scientists, researchers, midwives, nurses and support staff who work together with women to lead research into women’s health in the areas of reproduction, obstetrics and gynaecology. We conduct high quality studies that help improve the care of women before pregnancy, and women and their babies during and after pregnancy. 

We are primarily supported by the Nuffield Department of Women's & Reproductive Health, (part of the University of Oxford) the Oxford University Hospitals NHS Foundation Trust, and the Thames Valley & South Midlands Clinical Research Network, part of the National Institute for Health Research.

You can read about our current trials on this page below or find out more about OSPREA by clicking here. 

 

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PRE-PREGNANCY STUDIES 

Alfie 2

Alife 2Low-molecular-weight heparin to increase the chance of live birth in women with recurrent miscarriage and inherited thrombophilia (Anticoagulants for Living FoEtuses in women with recurrent miscarriage and inherited thrombophilia)

Who can participate? Women with recurrent miscarriage and inherited thrombophilia, planning a pregnancy or less than 7 weeks pregnant. 

Summary:  It is well known that some women whose blood tends to clot more than normal have an increased risk of miscarriage. That clotting tendency is called thrombophilia (sometimes also described as “sticky blood”). If this tendency has developed over time, perhaps as part of another illness, it is called “acquired thrombophilia” and treatment with anti-coagulant or “blood-thinning” medication has been shown to reduce the risk of miscarriage. 

The situation is different for women who have inherited thrombophilia  Read more

PREGNANCY STUDIES 

INGR1D Study in the Thames Valley

INGR1D - A large screening study in the Thames Valley to identify infants who are at risk of developing type 1 diabetes.

Who can participate? Any pregnant woman in the Thames Valley can participate.

Summary: In the first week of life, newborns are checked for treatable metabolic and hormonal disorders as part of the standard newborn screening tests. We would like to let you know about the option of another free screening test to identify children at high risk of developing type 1 diabetes. The test is available as part of a research study being carried out by staff of the NHS and the University of Oxford. This extra test can be performed on blood that has already been collected. There are no extra needles or blood tests required for this diabetes screening and taking part is voluntary. 

Read more

SAVE - A new treatment for pre-eclampsia. 

Who can participate? Pregnant women with pre-eclampsia before 32 weeks gestation.

Summary: Pre-eclampsia is a potentially serious condition that can put the health and wellbeing of the mother and the baby at risk. There are no effective treatments for pre-eclampsia, except to get the baby out (delivery). However, premature birth can lead to health problems for the baby. Babies born very prematurely may not be able to survive. Now, a clinical trial is being carried out to test whether a new medical device could effectively and safely treat pre-eclampsia. Read more

Mi Quit

Mi-QUIT - Smoking cessation in pregnancy. 

Who can participate? Women smoking during pregnancy.

Summary: This study is looking at whether pregnant women who smoke are interested in receiving support to stop smoking by text message and whether it can help them to quit. Read more

Bump

The BUMP Trial - Blood pressure monitoring in pregnancy

Who can participate? Pregnant women at risk of high blood pressure and pregnant women with high blood pressure

Summary: The BUMP trial is testing whether monitoring blood pressure at home during pregnancy can help the early detection of hypertension and pre-eclampsia. Around one in ten women will have high blood pressure in pregnancy. For some women this may be a sign of pre-eclampsia, which is usually detected in routine appointments through blood pressure and urine checks. We would like to find out if home blood pressure monitoring Read more 

REMIT2

REMIT2 Reduced Fetal Movement Intervention-2 Trial

Who can participate? Women who are 36 weeks or more pregnant and who have come to the hospital due to noticing a change in their baby’s movements.

Summary: It is common for pregnant women to attend ante-natal care in late pregnancy because they have noticed a change in their baby’s movements. This is called reduced fetal movement.  Most women who come with a change in their baby’s movements have a healthy pregnancy, although some have complications Read more

RESCEU

RESCEU - Burden of RSV Disease

Who can participate? Pregnant women and women in the postnatal period.

Summary: Respiratory Syncytial Virus (RSV) is the commonest virus causing coughs, colds and chest infections in infants. More than half of children will be infected in the first year of life, mostly during the winter. Most infections are mild (runny nose, cough and cold), but in some cases infants develop a severe chest infection requiring admission to hospital. In the winter months, RSV is responsible for around 1 in 6 of all hospital admissions in infants in the UK.  Read more 

The National Registry of Rare Kidney Diseases (RaDaR) is a research initiative by UK kidney specialist (the Renal Association and the UK Renal Registry). It is designed to gather information from patients with rare kidney disease and in particular women with chronic kidney disease (CKD). The group aims to look into how women with CKD cope with pregnancy and what can be done to improve care.

RaDaRKidney disease and pregnancy. 

Who can participate? Women with chronic kidney disease who have, or have had, a pregnancy.

Summary: The National Registry of Rare Kidney Diseases (RaDaR) is a research initiative by UK kidney specialist (the Renal Association and the UK Renal Registry). It is designed to gather information from patients with rare kidney disease and in particular women with chronic kidney disease (CKD). The group aims to look into how women with CKD cope with pregnancy and what can be done to improve care. Read more

Pre-eclampsia Study - Study of placental particle shedding and the maternal inflammatory response in pre-eclampsia

Who can participate? Women with pre-eclampsia and women without pre-eclampsia.

Summary: The Purpose of the study is to find out more about what causes and how to predict pre-eclampsia. We need to compare the results of certain tests on blood and placental samples from pregnant women with pre-eclampsia with those of women without pre-eclampsia. Read more


BIRTH STUDIES 

anode

ANODE - Prophylactic ANtibiotics for the prevention of infection following Operative DElivery. 

Who can participate? Women who have had their baby delivered by forceps or ventouse.

Read more

INGR1D Study in the Thames Valley

INGR1D A large screening study in the Thames Valley to identify infants who are at risk of developing type 1 diabetes.

Who can participate? Any pregnant woman in the Thames Valley can participate.

Summary: In the first week of life, newborns are checked for treatable metabolic and hormonal disorders as part of the standard newborn screening tests. We would like to let you know about the option of another free screening test to identify children at high risk of developing type 1 diabetes. The test is available as part of a research study being carried out by staff of the NHS and the University of Oxford. This extra test can be performed on blood that has already been collected. There are no extra needles or blood tests required for this diabetes screening and taking part is voluntary. 

Read more

POST NATAL STUDIES 

Cleft Collective

Cleft Study - The Cleft Collective Cohort Studies

Who can participate? Women who have received a diagnosis of cleft palate/lip during their pregnancy.

Summary: The Cleft Collective is the world’s largest cleft lip and palate research programme. We are developing two cohort studies. We will follow each family as their child grows up and keep in touch along the way. Read more