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The Oxford Safer Pregnancy Alliance (OSPREA) is a team of doctors, scientists, researchers, midwives, nurses and support staff who work together with women to lead research into women’s health in the areas of reproduction, obstetrics and gynaecology. We conduct high quality studies that help improve the care of women before pregnancy, and women and their babies during and after pregnancy. 

We are primarily supported by the Nuffield Department of Women's & Reproductive Health, (part of the University of Oxford) the Oxford University Hospitals NHS Foundation Trust, and the Thames Valley & South Midlands Clinical Research Network, part of the National Institute for Health Research.

You can read about our current trials on this page below or find out more about OSPREA by clicking here. 

 

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PRE-PREGNANCY STUDIES 

Alfie 2

Alife 2Low-molecular-weight heparin to increase the chance of live birth in women with recurrent miscarriage and inherited thrombophilia (Anticoagulants for Living FoEtuses in women with recurrent miscarriage and inherited thrombophilia)

Who can participate? Women with recurrent miscarriage and inherited thrombophilia, planning a pregnancy or less than 7 weeks pregnant. 

Summary:  It is well known that some women whose blood tends to clot more than normal have an increased risk of miscarriage. That clotting tendency is called thrombophilia (sometimes also described as “sticky blood”). If this tendency has developed over time, perhaps as part of another illness, it is called “acquired thrombophilia” and treatment with anti-coagulant or “blood-thinning” medication has been shown to reduce the risk of miscarriage. 

The situation is different for women who have inherited thrombophilia  Read more

PREGNANCY STUDIES 

INGR1D Study in the Thames Valley

INGR1D - A large screening study in the Thames Valley to identify infants who are at risk of developing type 1 diabetes.

Who can participate? Any pregnant woman in the Thames Valley can participate.

Summary: In the first week of life, newborns are checked for treatable metabolic and hormonal disorders as part of the standard newborn screening tests. We would like to let you know about the option of another free screening test to identify children at high risk of developing type 1 diabetes. The test is available as part of a research study being carried out by staff of the NHS and the University of Oxford. This extra test can be performed on blood that has already been collected. There are no extra needles or blood tests required for this diabetes screening and taking part is voluntary. 

Read more

The National Registry of Rare Kidney Diseases (RaDaR) is a research initiative by UK kidney specialist (the Renal Association and the UK Renal Registry). It is designed to gather information from patients with rare kidney disease and in particular women with chronic kidney disease (CKD). The group aims to look into how women with CKD cope with pregnancy and what can be done to improve care.

RaDaRKidney disease and pregnancy. 

Who can participate? Women with chronic kidney disease who have, or have had, a pregnancy.

Summary: The National Registry of Rare Kidney Diseases (RaDaR) is a research initiative by UK kidney specialist (the Renal Association and the UK Renal Registry). It is designed to gather information from patients with rare kidney disease and in particular women with chronic kidney disease (CKD). The group aims to look into how women with CKD cope with pregnancy and what can be done to improve care. Read more

Pre-eclampsia Study - Study of placental particle shedding and the maternal inflammatory response in pre-eclampsia

Who can participate? Women with pre-eclampsia and women without pre-eclampsia.

Summary: The Purpose of the study is to find out more about what causes and how to predict pre-eclampsia. We need to compare the results of certain tests on blood and placental samples from pregnant women with pre-eclampsia with those of women without pre-eclampsia. Read more


BIRTH STUDIES 

INGR1D Study in the Thames Valley

INGR1D A large screening study in the Thames Valley to identify infants who are at risk of developing type 1 diabetes.

Who can participate? Any pregnant woman in the Thames Valley can participate.

Summary: In the first week of life, newborns are checked for treatable metabolic and hormonal disorders as part of the standard newborn screening tests. We would like to let you know about the option of another free screening test to identify children at high risk of developing type 1 diabetes. The test is available as part of a research study being carried out by staff of the NHS and the University of Oxford. This extra test can be performed on blood that has already been collected. There are no extra needles or blood tests required for this diabetes screening and taking part is voluntary. 

Read more

POST NATAL STUDIES 

Cleft Collective

Cleft Study - The Cleft Collective Cohort Studies

Who can participate? Women who have received a diagnosis of cleft palate/lip during their pregnancy.

Summary: The Cleft Collective is the world’s largest cleft lip and palate research programme. We are developing two cohort studies. We will follow each family as their child grows up and keep in touch along the way. Read more

 BPiPP study

 

BPiPP study - Blood Pressure in the Postnatal Period

Who can participate?  You can take part if you recently had a baby in one of our participating hospitals. You may have experienced either normal or high blood pressure in your pregnancy.

Summary: We want to understand if women with high blood pressure in pregnancy, or immediately after, have different health problems and healthcare needs after birth, compared with women who did not have high blood pressure in pregnancy. Read more