Background & objectives Endometriosis, a chronic inflammatory condition, affects approximately 10 per cent of reproductive-age women in India. This study aimed to explore the experiences of women with endometriosis and their partners. Methods A qualitative exploratory study was conducted in two Indian States. In-depth interviews were conducted with 21 women (18-49 yr) with laparoscopically diagnosed endometriosis and 10 of their male partners. Interviews were conducted in local languages and English, with informed consent. Recordings were transcribed, coded, and analysed using Braun and Clarke's thematic analysis. Results The study revealed significant impacts of endometriosis on both women and men, including decreased quality of life, psychological effects, financial distress, strained intimate relationships and burden of infertility. Women experienced greater impacts, particularly in life opportunities and employment, social life and mental health. Delayed diagnosis and treatment exacerbated women's suffering, compromising their well-being and quality of life. Interpretation & conclusions This study emphasises the need for improved early diagnosis and treatment of endometriosis to mitigate its impact on women and their partners.