Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

BACKGROUND: Preterm birth at very low birth weight (VLBW, <1500g) has a multitude of consequences that extend to various aspects of adult life. Little is known about the long-term reproductive outcome of VLBW that survive to adulthood. AIMS: To evaluate the reproductive outcome of VLBW infants who survive to adulthood (next-generation). STUDY DESIGN: Retrospective cohort. SUBJECTS: Infants born at a single tertiary center between the years 1982-1997 who survived to 18years of age (first-generation). OUTCOME MEASURES: The number and the birth weight of offspring from adults born with VLBW were compared to those of other birth weight groups born in the same epoch: 1500-2499g, 2500-3799g (reference group) and ≥3800g. We calculated the ratio of actual compared to expected number of children in the next-generation for extreme birth weight parents, using the reference group as a control group and adjusting for birth year. Thereafter, we measured whether first-generation VLBW had an increased risk for a VLBW in the next-generation. RESULTS: After exclusions, we identified first-generation 67,183 births, including 618 (9.2%) VLBW. There were 193 males and 184 female VLBW infants who survived to adulthood. Both female and male first-generation patients from the VLBW group had half the reproductive rate relative for the normal birth weight group. After adjusting for parental age, male and female VLBW survivors had no significant risk for a VLBW neonate in the next-generation, however, the overall number of are small and may limit any conclusion. CONCLUSION: VLBW children who reach adulthood may be at a significantly lower reproductive capacity.

Original publication

DOI

10.1016/j.earlhumdev.2017.11.011

Type

Journal article

Journal

Early Hum Dev

Publication Date

01/2018

Volume

116

Pages

76 - 80

Keywords

Low birth weight, Prematurity, Preterm birth, Reproductive outcome, Very low birth weight