Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.

Gallagher CS., Mäkinen N., Harris HR., Rahmioglu N., Uimari O., Cook JP., Shigesi N., Ferreira T., Velez-Edwards DR., Edwards TL., Mortlock S., Ruhioglu Z., Day F., Becker CM., Karhunen V., Martikainen H., Järvelin M-R., Cantor RM., Ridker PM., Terry KL., Buring JE., Gordon SD., Medland SE., Montgomery GW., Nyholt DR., Hinds DA., Tung JY., 23andMe Research Team None., Perry JRB., Lind PA., Painter JN., Martin NG., Morris AP., Chasman DI., Missmer SA., Zondervan KT., Morton CC.

Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary cause for hysterectomy, leading to considerable morbidity and high economic burden. Here we conduct a GWAS meta-analysis in 35,474 cases and 267,505 female controls of European ancestry, identifying eight novel genome-wide significant (P 

DOI

10.1038/s41467-019-12536-4

Type

Journal article

Journal

Nat Commun

Publication Date

24/10/2019

Volume

10

Keywords

Adult, Ataxia Telangiectasia Mutated Proteins, Endometriosis, Female, Forkhead Box Protein O1, Genome-Wide Association Study, Humans, Leiomyoma, Mendelian Randomization Analysis, Menorrhagia, Middle Aged, Polymorphism, Single Nucleotide, Proportional Hazards Models, Receptor, Fibroblast Growth Factor, Type 4, Signal Transduction, Telomerase, Uterine Neoplasms, White People

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