MitOX 2017
Date: Friday 1st December 2017, 9.30am - 5.30pm
Venue: The Richard Doll Building, Old Road Campus, Headington, Roosevelt Drive, Oxford OX3 7LF.
Please join us for this one day meeting on the role of mitochondria in Health and Disease. We have high quality speakers attending, including:
- Grahame Hardie (Dundee) - Biguanides , AMPK and cancer therapeutics
- Joseph Bateman (Kings College) - Mitochondrial retrograde signalling in the nervous system
- Heather Mortiboys (Sheffield) - Mitochondria in neurodegeneration; a realistic therapeutic target?
- Andrew Murray (Cambridge) - Mitochondrial adaptations to high altitude in Himalayan Sherpas
- Cara Tomas (Newcastle) & Jiaboa Xu (Oxford) - Metabolic biomarkers in ME/CFS
- Craig Lygate (Oxford) - Cardioprotection by mitochondrial creatine kinase
- Charles Affourtit (Plymouth) - Unravelling the unusual bioenergetics of pancreatic beta cells
- Ivan Gout (UCL) – Protein CoAlation: a novel post-translational modification in redox regulation.
- Rita Horvath (Newcastle) – Genes and disease mechanisms in mitochondrial translation deficiencies
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Dunja Aksentijevic (Kings College, London) Causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy
AGENDA
09.00 Registration
Session 1 Chair: Lisa Heather
09.30 Welcome by Karl Morten (Oxford)
09.35 Craig Lygate (Oxford) - Cardioprotection by mitochondrial creatine kinase
10.00 Andrew Murray (Cambridge) - Mitochondrial adaptations to high altitude in Himalayan Sherpas
10.25 Tom Nicoll (MRC Harwell) Cardiac arrhythmia resulting from an accumulation of branched chain amin acids in a mouse line with a mutation in Bcat2
10.40 Dunja Aksentijevic (Kings College, London) Causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy
11.05 Coffee
Session 2 Chair: Karl Morten (Oxford)
11.30 Charles Affourtit (Plymouth) - Unravelling the unusual bioenergetics of pancreatic beta cells
11.55 Patrick Pollard tribute prize for work in Cancer Metabolism. Grahame Hardie (Dundee) - Biguanides, AMPK and cancer therapeutics
12.25 Jo Elson (Newcastle) - A novel approach for investigating mtDNA variation in the context of complex disease
12.40 Cara Tomas (Newcastle) & Jiaboa Xu (Oxford) - Metabolic biomarkers in ME/CFS
13.05 Lunch & Posters
Session 3 Chair: Jo Poulton (Oxford)
14.30 Joseph Bateman (Kings College) - Mitochondrial retrograde signalling in the nervous system
14.55 Heather Mortiboys (Sheffield) - Mitochondria in neurodegeneration; a realistic therapeutic target?
15.20 Rita Horvath (Newcastle) - Genes and disease mechanisms in mitochondrial translation deficiencies
15.45 Kenneth Pryde (Leicester) - Intra-mitochondrial proteolytic quality control selectively degrades complex I in depolarized mitochondria to constrain ROS production if mitophagy fails.
16.00 Tea/Coffee
Session 4 Chair: Paul Potter (MRC, Harwell)
16.30 Ivan Gout (UCL) - Protein CoAlation: a novel post-translational modification in redox regulation
16.55 Iain Johnston (Birmingham)-Selfish replication and cell-level selection explain complex tissue specific mtDNA segregation patterns
17.10 Eszter Dombi (Oxford) - Increased mitophagy and mitochondrial DNA (mtDNA) turnover in defects of mtDNA maintenance associated with severe neurodegenerative disease: towards new therapies
17.25 Alex Zhdanov (Cork) New bridge connecting mitochondria and translation: PolGX recruits the mitochondrial p32 protein for ribosome biogenesis
17.40 Drinks & Poster Results and Prize Giving!
19.30 MitOX Dinner
Registration fee £30.00 (concessions £15.00), lunch and refreshments are included.