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A study of more than 2,100 pregnant women across 18 countries worldwide has revealed that COVID-19 is associated with a higher risk of severe maternal and newborn complications than previously recognised.

Overview

INTERCOVID is a large, multi-national, prospective cohort study with the aim of assessing the effect of COVID-19 in pregnancy on maternal, fetal and neonatal outcomes worldwide.

 

LATEST NEWS

The results from the INTERCOVID study showing the risk of COVID-19 during pregnancy have been used by Ministry of Health in Argentina to underpin their recommendation that pregnant women should be prioritised for vaccination.

INTERCOVID news

 

 

COllaboRators

Contributors

JV, SK and AP conceptualized and designed the INTERCOVID Study. JV, SK and AP prepared the original protocol, with later input from AW and RC, and coordinated the project’s overall undertaking with invaluable input from AL, CV, JC, BE, EF, ZAB, JR and JT. RG, SR, CC, RC and AW undertook the data management and analysis in collaboration with JV and AP. JT and AP undertook the ongoing literature review and interpretation of published data. The Principal Investigators at each study site implemented the protocol at their respective institutions. CC, AW and RC led the quality control of data. JV, SK and AP wrote the manuscript with input from all co-authors. All co-authors read the manuscript and made suggestions on its content.

Members of the International Study on the Effects of Covid-19 in pregnancy on maternal and newborn outcomes in the INTERGROWTH-21st global network (The INTERCOVID Study) and its Committees.

Scientific Advisory Committee: Ana Langer (Chair), Cesar Victora, Jose Cordero, Brenda Eskenazi, Enrico Ferrazi, Zulfiqar Bhutta, Julian Robinson, Jim Thornton.

Coordinating Unit: Jose Villar, Aris Papageorghiou, Adele Winsey, Rachel Craik, Montserrat Izquierdo Renault, Stephen Kennedy, Ricardo Nieto, Albertina Rego, Josephine Agyeman-Duah.

Data Management Group: Carmen Condon, Robert Gunier, Stephen Rauch, Rachel Craik, Adele Winsey.

Participating institutions and Investigators

Argentina, Buenos Aires Clinica Otamendi: Carmen Vecciarell (Principal Investigator), Cristina Osio, Cecilia Baston, Marcela Volpe, Zenith Guzman, Hernan Jensen, Fernando Tami, Federico Crispin.

Argentina, Buenos Aires Hospital Materno Infantil Ramón Sarda: Ricardo Nieto and Constanza Soto Conti (co-Principal Investigators), Eugenia Luque, Jimena Melisa Vargas, Marta Isabel Lopez, Karen Zelada.

Argentina, Buenos Aires Hospital Universitario Austral: Maria Carola Capelli and Milagros Risso (co-Principal Investigators), Josefina Maria Bran.

Argentina, Buenos Aires Hospital Magdalena V de Martinez: Eduardo A Duro (Principal Investigator).

Argentina, Buenos Aires, Hospital Nacional Profesor Alejandro Posadas: Roberto Casale (Principal Investigator), Silvia Garcia, Alberto Ferreiros, Lucio Ribola, Grethelm Ferrufino, Karell Rojas, Dafne Sidiropulos, Silvana Varela.

Argentina, Buenos Aires, Hospital Municipal O. B de Lavignole: Mónica Savorani (Principal Investigator), Silvana Aguirre, Maria Rocio Tozzini.

Brazil, São Luis, Hospital Universitário da Universidade Federal do Maranhão: Marynéa Silva do Vale (Principal Investigator), Ana Claudia Garcia Marques, Patricia Franco Marques, Rebeca Aranha Arrais Santos Almeida.

Egypt, Tanta, Tanta University Hospital: Sherief Abd-Elsalam (Principal Investigator), Mohamed Elbahnasawy, Mai Khalaf, Mohamed Samir Abd El Ghafar, Eslam Saber Esmail.

France, Bordeaux, Bordeaux University Hospital: Loïc Sentilhes (Principal Investigator), Amaury Brot, Aurélien Mattuizzi, Clémence Houssin.

France, Paris, AP-HP, Hôpital Universitaire Necker-Enfants Malades: Laurent J Salomon (Principal Investigator), Joanna Sichitiu, Laurence Bussières.

France, Strasbourg, Hôpitaux Universitaires de Strasbourg: Philippe Deruelle (Principal Investigator), Fanny De Marcillac, Mary Pontvianne, Georges-Emmanuel Roth, Charlotte Jouffrieau, Sylvain Hufschmitt-Henry, Valentine Bergthold, Mathilde Airoldi, Olivier Behra, Julie Delplanque, Coraline Schutz.

Ghana, Asankragua Fr. Thomas Alan Rooney Memorial Hospital: Vincent Bizor Nachinab (Principal Investigator), Bright Sandow, Priscilla Baffour Kyeremeh, Rita Akpene Kumi, Thomas Asechaab and Grace Hanson

Ghana, National Catholic Health Service, Directorate: George Adjei, Anita Appiah, Roberta Ama Asiedu, Ivan Essegbey.

Ghana, Nkawkaw Holy Family Hospital: Eric Baafi (Principal Investigator), Genevieve Insaidoo.

India Faridabad, Employee's State Insurance Corporation Medical College and Hospital and affiliated Badshah Khan Civil Hospital, Haryana, India: Ramachandran Thiruvengadam and Shinjini Bhatnagar (co-Principal Investigators), Vandita Bhartia, Mudita Wahi, Anil K. Pandey, Jagadish Chandra Sharma, Rajesh Dhiman, GARBH-Ini- DBT India Consortium for COVID Research Collaboration.

Indonesia, Surabaya, Medical Faculty Universitas Airlangga - Dr. Soetomo General Academic Hospital: Ernawati Ernawati (Principal Investigator), Hendy Hendarto, Erry Gumilar, Aditiawarman.

Italy, Brescia, Spedali Civili and University of Brescia: Federico Prefumo (Principal Investigator), Roberta Castellani, Marta Papaccio.

Italy, Milan, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico: Paola Roggero and Enrico Ferrazzi (co-Principal Investigators), Camilla Menis, Michela Perrone, Enrico Iurlaro.

Italy, Milan, Ospedale Luigi Sacco: Valeria Savasi (Principal Investigator), Silvia Corti, Francesca Rana.

Italy, Milan, IRCCS San Raffaele Hospital and University: Paolo Ivo Cavoretto (Principal Investigator), Massimo Candiani, Giulia Bonavina.

Italy Milan, Ospedale Vittore Buzzi: Irene Cetin (Principal Investigator), Alice Zavatta, Stefania Livio.

Italy, Pavia, University of Pavia and Fondazione IRCCS Policlinico San Matteo: Hellas Cena and Rosa Maria Cerbo (co Principal Investigators), Debora Porri, Rachele De Giuseppe, Arsenio Spinillo, Annachiara Licia Scatigno, Francesca Perotti.

Italy, Turin, Ospedale Infantile Regina Margherita-Sant'Anna, Città della Salute e della Scienza di Torino: Francesca Giuliani and Manuela Oberto (co-Principal Investigators), Enrico Bertino, Pietro Gaglioti, Cristian Romolo Macchione, Francesca Carpano Maglioli.

Japan, Tokyo, The Jikei University School of Medicine: Ken Takahashi (Principal Investigator), Osamu Samura.

Japan, Tokyo, Keio University School of Medicine: Mamoru Tanaka and Satoru Ikenoue (co-Principal Investigators), Daigo Ochiai, Yoshifumi Kasuga, Miho Iida.

North Macedonia, Prilep, General Hospital Borka Taleski: Gabriela Tavchioska (Principal Investigator).

North Macedonia, Prilep, General Hospital Kumanovo: Aleksandra Hristova (Principal Investigator).

Mexico, Mexico City, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes: Jorge Arturo Cardona-Perez (Principal Investigator), Sandra Acevedo-Gallegos, Irma Alejandra Coronado-Zarco, Brenda Ivette Frías, Addy Cecilia Helguera-Repetto, Maria José Rodriguez Sibaja, Isabel Villegas-Mota, Maria Yolotzin Valdespino.

Mexico, Mexico City, Lic. Adolfo López Mateos ISSSTE: Perla K García-May (Principal Investigator), Alberto Almanza Aguilar, Sanjuanita Gonzalez Garza, Lorena Gomez Aldape, Alejandra Loera Olvera, Paulina Soriano Cabelo.

Nigeria, Bauchi, Abubakar Tafawa Balewa University Teaching Hospital: Muhammad Baffah Aminu (Principal Investigator), Tiamiyu Ismail.

Nigeria, Calabar, University of Calabar Teaching Hospital: Saturday Etuk (Principal Investigator), Chinyere Akpanika, Komommo Okpebri, Etim Ekanem, Ubong Akpan.

Nigeria, Gombe, Federal Teaching Hospital Gombe: Babagana Bako (Principal Investigator), Yahaya Musa Suleiman.

Nigeria, Ibadan, University College Hospital: Adejumoke Idowu Ayede and Yetunde John-Akinola (co-Principal Investigators), Oladapo OlayemI, Olufisayo Christopher Ologunore.

Nigeria, Lagos, Mainland Hospital Yaba: Abimbola Bowale (Principal Investigator), Tope Gbagada Ogunniyan.

Nigeria, Kano State, Aminu Kano Teaching Hospital: Hadiza Galadanci and Fatima Hassan-Hanga (co-Principal Investigators), Mahmoud Magashi.

Nigeria, Kano State, Muhammad Abdullahi Wase Teaching Hospital: Mustapha Ado Usman (Principal Investigator), Iman Haruna, Maryam Sulaiman, Rahila Garba, Badiyya Sayyidi, Hanifa Datti, Frank Akabudu, Abdurrahman Ali Bunawa, Amira Aminu.

Pakistan, Karachi, The Aga Khan University Hospital: Shabina Ariff (Principal Investigator), Ghulam Zainab, Lumaan Shaikh, Khalil Ahmed.

Russia, Moscow, National Medical Research Center for Obstetrics, Gynecology & Perinatology: Alexey Kholin (Principal Investigator), Irina Yakovleva, Aleksander Gus, Alexander Sencha, Roman Shmakov, Gennady Sukhikh.

Spain, Barcelona, Hospital Universitari Vall d’Hebron: Nerea Maiz (Principal Investigator), Berta Serrano, Ester del Baco, Marta Miguez, Ana Perestelo, Lidia Barberán, Cristina Tusquets, Montserrat Capell, Clementina de Antonio, Judit Gil.

Spain, Zaragoza, Hospital Clínico Universitario Lozano Blesa Zaragoza: Daniel Oros (Principal Investigator), Sara Ruiz-Martinez, Marta Fabre, Cristina Paules.

Switzerland, Geneva, Hôpitaux Universitaires de Genève: Anne Caroline Benski (Principal Investigator), Martinez de Tejada Weber, Véronique Othenin-Girard, Monia Moreau, Dominique Deletraz, David Baud.

UK, London, St George's University Hospitals NHS Foundation Trust: Aris Papageorghiou (Principal Investigator), Becky Liu, Matthew Cauldwell, Yaa Acheampong, Danielle Hake, Sophie Robinson, Rosemary Nyamboya.

UK, London, University College Hospitals NHS Foundation Trust: Raffaele Napolitano (Principal Investigator), Laura Salazar, Alex Fry, Hilary Hewitt.

UK, Oxford, Oxford University Hospitals NHS Foundation Trust: Jose Villar, Stephen Kennedy, Sonia Deantoni (co-Principal Investigators), Angelika Capp, Lotoyah Carty, Kate Dixon, Yvonne Nsiah, Fenella Roseman.

USA, Boston, MA, Brigham and Women's Hospital: Sarah Rae Easter (Principal Investigator).

USA, Boston, MA, Tufts Medical Center: Mohak Mhatre (Principal Investigator), Jenny Koenig, Arome Obende.

USA, Chicago, IL, Mercy Hospital and Medical Center: Jagjit Singh Teji (Principal Investigator), Michelle Firlit.

USA, Seattle, WA, University of Washington: Michael Gravett (Principal Investigator), Lavone E Simmons.